165682-82-6

Basic information

• Product Name: 2-(4-Chloro-phenylamino)-thiazole-4-carboxylic acid
• Synonyms: 2-[(4-Chlorophenyl)amino]-1,3-thiazole-4-carboxylicacid
• CAS NO: 165682-82-6
• Molecular Formula: C₁₀H₇ClN₂O₂S
• Molecular Weight: 254.7
• Product Categories: pharmacetical
• Mol File: 165682-82-6.mol
• Article Data: 6

Chemical Properties

• Melting Point: 277-279°
• Boiling Point: 458.9°Cat760mmHg
• Flash Point: 231.3°C
• Appearance: /
• Density: 1.565g/cm³
• Vapor Pressure: 3.24E-09mmHg at 25°C
• Refractive Index: 1.715
• Storage Temp.: 2-8°C
• PKA: 1.13±0.10(Predicted)
• CAS DataBase Reference: 2-(4-Chloro-phenylamino)-thiazole-4-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-Chloro-phenylamino)-thiazole-4-carboxylic acid(165682-82-6)
• EPA Substance Registry System: 2-(4-Chloro-phenylamino)-thiazole-4-carboxylic acid(165682-82-6)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 165682-82-6(Hazardous Substances Data)

Usage

General Description

2-(4-Chloro-phenylamino)-thiazole-4-carboxylic acid is a chemical compound that belongs to the group of thiazoles. Thiazoles are aromatic heterocyclic compounds consisting of a five-membered C3NS ring. They are known to exhibit various biological activities, and are commonly used in medicinal chemistry to discover new drugs. This particular compound, with its chlorinated phenylamino group and carboxylic acid group, might demonstrate unique physicochemical properties and biological activity. Given its complex structure, it's likely synthesized in the laboratory and used for research purposes in pharmaceutical or chemical industries. It is critical to handle it with appropriate safety measures due to potential risks associated with any chemical substance.

InChI:InChI=1/C10H7ClN2O2S/c11-6-1-3-7(4-2-6)12-10-13-8(5-16-10)9(14)15/h1-5H,(H,12,13)(H,14,15)

Upstream product

• 106-47-8 4-chloro-aniline 
• 52077-66-4 ethyl N-[(4-chlorophenyl)carbamothioyl]carbamate 
• 3696-23-9 N-(4-chlorophenyl)thiourea 
• 165682-93-9 ethyl 2-((4-chlorophenyl)amino)thiazole-4-carboxylate 

Downstream Products

• 1450648-66-4 N-(4-chlorophenyl)-4-[(4-methyl-1-piperidinyl)carbonyl]-1,3-thiazol-2-amine 

Relevant articles and documents

Disrupting the Conserved Salt Bridge in the Trimerization of Influenza A Nucleoprotein

Antiviral drug resistance in influenza infections has been a major threat to public health. To develop a broad-spectrum inhibitor of influenza to combat the problem of drug resistance, we previously identified the highly conserved E339?R416 salt bridge of the nucleoprotein trimer as a target and compound 1 as an inhibitor disrupting the salt bridge with an EC50 = 2.7 μM against influenza A (A/WSN/1933). We have further modified this compound via a structure-based approach and performed antiviral activity screening to identify compounds 29 and 30 with EC50 values of 110 and 120 nM, respectively, and without measurable host cell cytotoxicity. Compared to the clinically used neuraminidase inhibitors, these two compounds showed better activity profiles against drug-resistant influenza A strains, as well as influenza B, and improved survival of influenza-infected mice.

The discovery of potent blockers of the canonical transient receptor channels, TRPC3 and TRPC6, based on an anilino-thiazole pharmacophore

Lead optimization of piperidine amide HTS hits, based on an anilino-thiazole core, led to the identification of analogs which displayed low nanomolar blocking activity at the canonical transient receptor channels 3 and 6 (TRPC3 & 6) based on FLIPR (carbac

THIAZOLES DERIVATIVES AS AMPK ACTIVATOR

The present application provides novel thiazole derivatives that are useful as activators of Adenosine 5'-Monophosphate-Activated Protein Kinase and pharmaceutical compositions containing such compounds.