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1-(2,4-dimethyl-1,3-thiazol-5-yl)methanamine, also known as DMTA, is a chemical compound characterized by a thiazole structure and a primary amine functional group. It is recognized for its role as a building block in the synthesis of various bioactive molecules and agrochemicals, and is also under investigation for its potential antimicrobial and antiviral properties. With a molecular formula of C6H10N2S and a molecular weight of 142.23 g/mol, DMTA is typically a colorless to pale yellow liquid at room temperature. Due to its toxicity and potential health hazards, it requires careful handling.

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  • 165736-07-2 Structure
  • Basic information

    1. Product Name: 1-(2,4-DIMETHYL-1,3-THIAZOL-5-YL)METHANAMINE
    2. Synonyms: 1-(2,4-DIMETHYL-1,3-THIAZOL-5-YL)METHANAMINE;(2,4-Dimethylthiazol-5-yl)methanamine;1-(2,4-dimethyl-1,3-thiazol-5-yl)methanamine(SALTDATA: 2HCl);C-(2,4-DiMethyl-thiazol-5-yl)-MethylaMine;(2,4-DiMethyl-thiazol-5-yl)MethylaMine;(2,4-diMethyl-1,3-thiazol-5-yl)MethanaMine;5-ThiazoleMethanaMine,2,4-diMethyl-;2,4-Dimethyl-5-thiazolemethanamine
    3. CAS NO:165736-07-2
    4. Molecular Formula: C6H10N2S
    5. Molecular Weight: 142.22
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 165736-07-2.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 243.34 °C at 760 mmHg
    3. Flash Point: 100.969 °C
    4. Appearance: /
    5. Density: 1.141 g/cm3
    6. Vapor Pressure: 0.0323mmHg at 25°C
    7. Refractive Index: 1.568
    8. Storage Temp.: 2-8°C
    9. Solubility: N/A
    10. PKA: 8.31±0.29(Predicted)
    11. CAS DataBase Reference: 1-(2,4-DIMETHYL-1,3-THIAZOL-5-YL)METHANAMINE(CAS DataBase Reference)
    12. NIST Chemistry Reference: 1-(2,4-DIMETHYL-1,3-THIAZOL-5-YL)METHANAMINE(165736-07-2)
    13. EPA Substance Registry System: 1-(2,4-DIMETHYL-1,3-THIAZOL-5-YL)METHANAMINE(165736-07-2)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 165736-07-2(Hazardous Substances Data)

165736-07-2 Usage

Uses

Used in Pharmaceutical and Chemical Research:
1-(2,4-dimethyl-1,3-thiazol-5-yl)methanamine is used as a building block for the synthesis of bioactive molecules and agrochemicals, contributing to the development of new drugs and chemical products.
Used in Antimicrobial Applications:
1-(2,4-dimethyl-1,3-thiazol-5-yl)methanamine is studied for its potential antimicrobial properties, which could be utilized in the development of new antimicrobial agents to combat resistant bacteria.
Used in Antiviral Applications:
1-(2,4-dimethyl-1,3-thiazol-5-yl)methanamine is also being investigated for its potential antiviral properties, which may lead to its use in the creation of new antiviral medications to treat viral infections.
Used in Chemical Industry:
In the chemical industry, 1-(2,4-dimethyl-1,3-thiazol-5-yl)methanamine is used as a reagent or intermediate in the production of various chemical compounds, leveraging its unique structure and functional group for specific chemical reactions.

Check Digit Verification of cas no

The CAS Registry Mumber 165736-07-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,5,7,3 and 6 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 165736-07:
(8*1)+(7*6)+(6*5)+(5*7)+(4*3)+(3*6)+(2*0)+(1*7)=152
152 % 10 = 2
So 165736-07-2 is a valid CAS Registry Number.
InChI:InChI=1/C6H10N2S/c1-4-6(3-7)9-5(2)8-4/h3,7H2,1-2H3

165736-07-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name (2,4-dimethyl-1,3-thiazol-5-yl)methanamine

1.2 Other means of identification

Product number -
Other names 2,4-Dimethyl-5-Thiazolemethanamine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:165736-07-2 SDS

165736-07-2Downstream Products

165736-07-2Relevant articles and documents

Design, synthesis and biological evaluation of novel thiazole-derivatives as mitochondrial targeting inhibitors of cancer cells

Dang, Xin,Lei, Shuwen,Luo, Shuhua,Hu, Yixin,Wang, Juntao,Zhang, Dongdong,Lu, Dan,Jiang, Faqin,Fu, Lei

, (2021/06/16)

Mitochondria are pivotal energy production sources for cells to maintain necessary metabolism activities. Targeting dysfunctional mitochondrial features has been a hotspot for mitochondrial-related disease researches. Investigation with cancerous mitochondrial metabolism is a continuing concern within tumor therapy. Herein, we set out to assess the anti-cancer activities of a novel family of TPP-thiazole derivatives based on our earlier research on mitochondrial targeting agents. Specifically, we designed and synthesized a series of TPP-thiazole derivatives and revealed by the MTT assay that most synthesized compounds effectively inhibited three cancer cell lines (HeLa, PC3 and MCF-7). After structure modifications, we explored the SAR relationships and identified the most promising compound R13 (IC50 of 5.52 μM) for further investigation. In the meantime, we performed ATP production assay to assess the selected compounds inhibitory effect on HeLa cells energy production. The results displayed the test compounds significantly restrained ATP production of cancer cells. Overall, we have designed and synthesized a series of compounds which exhibited significant cytotoxicity against cancer cells and effectively inhibited mitochondrial energy production.

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