95453-54-6

Basic information

• Product Name: 2,4-DIMETHYL-1,3-THIAZOLE-5-CARBALDEHYDE
• Synonyms: IFLAB-BB F2124-0220;2,4-DIMETHYL-1,3-THIAZOLE-5-CARBALDEHYDE;2,4-DIMETHYL-1,3-THIAZOLE-5-CARBOXALDEHYDE;2,4-DIMETHYLTHIAZOLE-5-CARBOXALDEHYDE;5-Thiazolecarboxaldehyde, 2,4-dimethyl- (9CI);2,4-Dimethylthiazole-5-carbaldehyde;2,4-Dimethyl-5-formyl-1,3-thiazole;5-Thiazolecarboxaldehyde,2,4-diMethyl-
• CAS NO: 95453-54-6
• Molecular Formula: C₆H₇NOS
• Molecular Weight: 141.19
• Product Categories: ALDEHYDE;Building Blocks;Heterocyclic Building Blocks;Thiazoles
• Mol File: 95453-54-6.mol
• Article Data: 2

Chemical Properties

• Melting Point: 23-27 °C(lit.)
• Boiling Point: 64 °C
• Flash Point: 210 °F
• Appearance: /
• Density: 1.213 g/cm³
• Vapor Pressure: 0.041mmHg at 25°C
• Refractive Index: 1.588
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 2.25±0.10(Predicted)
• CAS DataBase Reference: 2,4-DIMETHYL-1,3-THIAZOLE-5-CARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-DIMETHYL-1,3-THIAZOLE-5-CARBALDEHYDE(95453-54-6)
• EPA Substance Registry System: 2,4-DIMETHYL-1,3-THIAZOLE-5-CARBALDEHYDE(95453-54-6)

Safety Data

• Hazard Codes: Xn
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 95453-54-6(Hazardous Substances Data)

Usage

Description

2,4-DIMETHYL-1,3-THIAZOLE-5-CARBALDEHYDE is an organic compound that serves as a key intermediate in the synthesis of various chemical compounds. It is characterized by its unique thiazole ring structure and aldehyde functional group, which contribute to its reactivity and potential applications in different industries.

Uses

Used in Pharmaceutical Industry:
2,4-DIMETHYL-1,3-THIAZOLE-5-CARBALDEHYDE is used as a synthetic intermediate for the development of tetrasubstituted ethylenediamine-based derivatives. These derivatives have been found to be potent anticancer histone-fold transcription factor (hFTase) inhibitors, playing a crucial role in the regulation of cellular processes and exhibiting potential as therapeutic agents for cancer treatment.
Used in Biochemical Research:
2,4-DIMETHYL-1,3-THIAZOLE-5-CARBALDEHYDE is also used in the preparation of piperazinyl benzimidazoles, which are known as antagonists of the gonadotropin-releasing hormone receptor. These compounds have potential applications in the study and treatment of various hormonal disorders and reproductive health issues, as they can modulate the activity of the gonadotropin-releasing hormone receptor, affecting the release of hormones involved in the regulation of reproductive functions.

InChI:InChI=1/C6H7NOS/c1-4-6(3-8)9-5(2)7-4/h3H,1-2H3

Upstream product

• 50382-32-6 (2,4-dimethyl-1,3-thiazol-5-yl)methanol 
• 79-37-8 oxalyl dichloride 
• 7210-77-7 ethyl 2,4-dimethyl-1,3-thiazole-5-carboxylate 

Downstream Products

• 874278-06-5 C₂₇H₃₃N₅S 
• 881687-59-8 tert-butyl-2-{[4-({[(2,4-dimethyl-1,3-thiazol-5-yl)methyl]amino}methyl)phenyl]thio}-2-methyl-propanoate 
• 50382-32-6 (2,4-dimethyl-1,3-thiazol-5-yl)methanol 
• 165736-07-2 1-(2,4-dimethyl-1,3-thiazol-5-yl)methanamine 

Relevant articles and documents

BENZAZEPINE DERIVATIVES, PROCESS FOR THE PREPARATION OF THE SAME AND USES THEREOF

Compounds of the general formula (I): or salts thereof, which exhibit CCR5 antagonism and exert preventive and therapeutic effects against HIV infections: wherein R1 is a 5- to 6-membered aromatic ring which bears a substituent represented by the general formula: R-Z1-X-Z2- (wherein R1 is hydrogen or optionally substituted hydrocarbyl; X is optionally substituted alkylene; and Z1 and Z2 are each a heteroatom) and may be further substituted, with R being optionally bonded to the aromatic ring to form another ring; Y is optionally substituted imino; and R2 and R3 are each optionally substituted aliphatic hydrocarbyl or an optionally substituted hetero-alicyclic group.