165749-18-8Relevant articles and documents
Cooperativity of Catechols and Amines in High-Performance Dry/Wet Adhesives
Delparastan, Peyman,Gerst, Matthias,Messersmith, Phillip B.,Ney, Max R.,Tiu, Brylee David B.
, p. 16616 - 16624 (2020)
The outstanding adhesive performance of mussel byssal threads has inspired materials scientists over the past few decades. Exploiting the amino-catechol synergy, polymeric pressure-sensitive adhesives (PSAs) have now been synthesized by copolymerizing tra
Colorant with double catechol structure, preparation method and applications thereof
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Paragraph 0097; 0101-0102; 0108; 0112-0113; 0117; 0121-0122, (2020/05/30)
The invention relates to the technical field of organic colorants, and particularly provides a colorant with a double catechol structure, a preparation method and applications thereof, wherein the colorant has a structural general formula represented by a
Bioinspired Design Provides High-Strength Benzoxazine Structural Adhesives
Higginson, Cody J.,Malollari, Katerina G.,Xu, Yunqi,Kelleghan, Andrew V.,Ricapito, Nicole G.,Messersmith, Phillip B.
supporting information, p. 12271 - 12279 (2019/08/01)
A synthetic strategy to incorporate catechol functional groups into benzoxazine thermoset monomers was developed, leading to a family of bioinspired small-molecule resins and main-chain polybenzoxazines derived from biologically available phenols. Lap-she
TRPV1 MODULATOR COMPOUNDS
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Paragraph 0111; 0116, (2018/11/27)
The present invention relates to TRPV1 modulator compounds of formula (I) or their pharmaceutically or veterinary acceptable salts, or their stereoisomers or mixtures thereof, wherein m is an integer selected from 1 to 3; R1, R2, R6 and R6', are independently selected from H, (C1-C8)alkyl, unsaturated (C2-C8)hydrocarbon, and (C3-C6)cycloalkyl, being these groups optionally substituted; R3 is hydrogen or halogen; R4 is selected from H, (C1-C8)alkyl, unsaturated (C2-C8)hydrocarbon, (C3-C6)cycloalkyl, (C6-C12)aryl, and (C5-C12)heteroaryl, being these groups optionally substituted; and R5 is selected from (C3-C28)alkyl, unsaturated (C3-C28)hydrocarbon, (C6-C12)aryl, and (C5-C12)heteroaryl, being these groups optionally substituted. It also relates to a process for their preparation, to pharmaceutical, veterinary or cosmetic compositions containing them, and to their pharmaceutical, veterinary and cosmetic applications.
CONJUGATES OF HYALURONIC ACID AND ANTICANCER COMPOUNDS
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Paragraph 00151, (2018/02/28)
The present invention relates to a polymer-drug conjugate wherein the polymer is hyaluronic acid and the drug is an anticancer compound. The anticancer compound is covalently linked to the hyaluronic acid by a pH-labile boronic acid-containing linkage. These conjugates can be used for the treatment of cancer.
Catechol-Functionalized Synthetic Polymer as a Dental Adhesive to Contaminated Dentin Surface for a Composite Restoration
Lee, Sang-Bae,González-Cabezas, Carlos,Kim, Kwang-Mahn,Kim, Kyoung-Nam,Kuroda, Kenichi
, p. 2265 - 2275 (2015/08/19)
This study reports a synthetic polymer functionalized with catechol groups as dental adhesives. We hypothesize that a catechol-functionalized polymer functions as a dental adhesive for wet dentin surfaces, potentially eliminating the complications associa
Design and synthesis of a photocleavable biotin-linker for the photoisolation of ligand-receptor complexes based on the photolysis of 8-quinolinyl sulfonates in aqueous solution
Aoki, Shin,Matsuo, Nanako,Hanaya, Kengo,Yamada, Yasuyuki,Kageyama, Yoshiyuki
experimental part, p. 3405 - 3413 (2009/09/25)
The ability of avidin (Avn) to form strong complex with biotin (Btn) is frequently used in the detection and isolation of biomolecules in biochemical, analytical, and medicinal research. The fact that the binding is nealy irreversible, however, constitutes a drawback in term of the isolation and purification of intact biomolecules. We recently found that 8-quinolinyl esters of aromatic or aliphatic sulfonic acids undergo photolysis when irradiated at 300-330 nm in aqueous solution at neutral pH. In this work, a biotin-dopamine (BD) conjugate containing a photocleavable 8-quinolinyl benzenesulfonate (QB) linker, BDQB, was designed and synthesized for use in the efficient recovery of dopamine-protein (e.g., antibody) complexes from an Avn-Btn system. The complexation of BDQB with a primary anti-dopamine antibody (anti-dopamine IgG1 from mouse) on an Avn-coated plate was confirmed by an enzyme-linked immunosorbent assay (ELISA) utilizing a secondary antibody (anti-IgG1 antibody) conjugated with horseradish peroxidase (HRP). Upon the photoirradiation (at 313 nm) of the BDQB-IgG1 complex, the release of dopamine-IgG1 complex was confirmed by ELISA. Characterization of the resulting photoreleased dopamine-anti-dopamine IgG1 complex was performed by SDS-PAGE and Western blot.
Design, synthesis and biological evaluation of glutathione peptidomimetics as components of anti-Parkinson prodrugs
More, Swati S.,Vince, Robert
supporting information; experimental part, p. 4581 - 4588 (2009/06/06)
Plethoras of CNS-active drugs fail to effect their pharmacologic response due to their in vivo inability to cross the blood-brain barrier (BBB). The classical prodrug approach to overcome this frailty involves lipophilic derivatives of the polar drug, but we herein report a novel approach by which endogenous transporters at BBB are exploited for brain drug delivery. The crucial role played by glutathione in pathogenesis of Parkinson's and the presence of its influx transporters at the basolateral membrane of BBB served as the basis for our anti-Parkinson prodrug design strategy. A metabolically stable analogue of glutathione is used as a carrier for delivery of dopamine and adamantamine. An account of successful syntheses of these prodrugs along with their transport characteristics and stability determination is discussed.
Novel L-Dopa and dopamine prodrugs containing a 2-phenyl-imidazopyridine moiety
Denora, Nunzio,Laquintana, Valentino,Lopedota, Angela,Serra, Mariangela,Dazzi, Laura,Biggio, Giovanni,Pal, Dhananjay,Mitra, Ashim K.,Latrofa, Andrea,Trapani, Giuseppe,Liso, Gaetano
, p. 1309 - 1324 (2008/02/04)
Purpose. The aim of this study was to gain insight into the feasibility of enhancing the delivery of L-Dopa and dopamine to the brain by linking these neurotransmitters and L-Dopa ethyl ester to 2-phenyl-3-carboxymethyl- imidazopyridine compounds giving r
A new synthesis of phenolic 1-hydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-Benzazepines
Ikeuchi, Motoki,Ikeuchi, Miyuki,Inoue, Kumiko,Yamamoto, Syuhei,Yamauchi, Aiko,Kihara, Masaru
, p. 2925 - 2935 (2007/10/03)
7,8-Dihydroxy-1-phenyl- and 1-(3- and 4-hydroxyphenyl)-1-hydroxy-2,3,4,5-tetrahydro-1H-3-benzazepine derivatives (2a,b) and (3a-c) were synthesized by intramolecular Barbier reaction of N-(2-iodophenethyl)-phenacylamines (5a,b) and (12a-c) with n-C4