877128-41-1

Upstream product

• 62-31-7 dopamine hydrochloride 
• 107-31-3 Methyl formate 
• 165749-18-8 2-(3,4-bis((tert-butyldimethylsilyl)oxy)phenyl)ethan-1-amine 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 109-94-4 formic acid ethyl ester 

Downstream Products

• 877128-47-7 N-{2-[4,5-di(t-butyldimethylsilyloxy)-2-iodophenyl]ethyl}-N-methylphenacylamine 
• 877128-49-9 7,8-di(t-butyldimethylsilyloxy)-1-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine 
• 877128-45-5 2-[4,5-di(t-butyldimethylsilyloxy)-2-iodophenyl]-N-methylethylamine 
• 877128-43-3 2-[4,5-di(t-butyldimethylsilyloxy)-2-iodophenyl]-N-formylethylamine 

Relevant academic research and scientific papers

TRPV1 MODULATOR COMPOUNDS

The present invention relates to TRPV1 modulator compounds of formula (I) or their pharmaceutically or veterinary acceptable salts, or their stereoisomers or mixtures thereof, wherein m is an integer selected from 1 to 3; R1, R2, R6 and R6', are independently selected from H, (C1-C8)alkyl, unsaturated (C2-C8)hydrocarbon, and (C3-C6)cycloalkyl, being these groups optionally substituted; R3 is hydrogen or halogen; R4 is selected from H, (C1-C8)alkyl, unsaturated (C2-C8)hydrocarbon, (C3-C6)cycloalkyl, (C6-C12)aryl, and (C5-C12)heteroaryl, being these groups optionally substituted; and R5 is selected from (C3-C28)alkyl, unsaturated (C3-C28)hydrocarbon, (C6-C12)aryl, and (C5-C12)heteroaryl, being these groups optionally substituted. It also relates to a process for their preparation, to pharmaceutical, veterinary or cosmetic compositions containing them, and to their pharmaceutical, veterinary and cosmetic applications.

A new synthesis of phenolic 1-hydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-Benzazepines

7,8-Dihydroxy-1-phenyl- and 1-(3- and 4-hydroxyphenyl)-1-hydroxy-2,3,4,5-tetrahydro-1H-3-benzazepine derivatives (2a,b) and (3a-c) were synthesized by intramolecular Barbier reaction of N-(2-iodophenethyl)-phenacylamines (5a,b) and (12a-c) with n-C4