165807-04-5

Basic information

• Product Name: pyridine-4-carboxaldehyde (1-benzylpiperidin-4-yl)imine
• Synonyms: pyridine-4-carboxaldehyde (1-benzylpiperidin-4-yl)imine
• CAS NO: 165807-04-5
• Molecular Weight: 279.385
• Mol File: 165807-04-5.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: pyridine-4-carboxaldehyde (1-benzylpiperidin-4-yl)imine(CAS DataBase Reference)
• NIST Chemistry Reference: pyridine-4-carboxaldehyde (1-benzylpiperidin-4-yl)imine(165807-04-5)
• EPA Substance Registry System: pyridine-4-carboxaldehyde (1-benzylpiperidin-4-yl)imine(165807-04-5)

Safety Data

• Hazardous Substances Data: 165807-04-5(Hazardous Substances Data)

Upstream product

• 872-85-5 pyridine-4-carbaldehyde 
• 50541-93-0 4-amino-1-benzylpiperidine 

Downstream Products

• 165806-47-3 1-(1-Benzylpiperidin-4-yl)-4-(4-fluorophenyl)-5-(pyridin-4-yl)-imidazole 
• 321344-92-7 (+/-)-α-(1-benzylpiperidin-4-yl)amino-α-(pyridin-4-yl)acetonitrile 

Relevant articles and documents

Heteroaryl-substituted pyrrole derivatives, their preparation and their therapeutic uses

Compounds having activity against production of an inflammatory cytokine of formula (I)′: 1A′ is pyrrole; R1′ is phenyl or naphthyl; R2′ is pyridyl or pyrimidinyl; R3′ is (IIa)′, (IIb)′ or (IIc)′: 2m′ is 1; E′ is nitrogen; D′ is >C(R5′)—, R5′ is hydrogen, Substituent α′ or Substituent β′; B′ is nitrogen-containing 5-membered heterocyclic; R4′ is 1 to 3 substituents from Substituent α′, Substituent β′ and Substituent γ′; R1′ and R3′ are bonded to two atoms of the pyrrole adjacent to the pyrrole atom bonded to R2′; Substituent α′ is hydroxyl, nitro, cyano, halogen, alkoxy, halogeno alkoxy, alkylthio, halogeno alkylthio or —NRa′Rb′; Ra′ and Rb′ are hydrogen, alkyl, alkenyl, alkynyl, aralkyl or alkylsulfonyl, or Ra′ and Rb′ with the nitrogen atom form a heterocyclyl; Substituent β′ is alkyl, alkenyl, alkynyl, aralkyl or cycloalkyl; Substituent γ′ is oxo, hydroxyimino, alkoxyimino, alkylene, alkylenedioxy, alkylsulfinyl, alkylsulfonyl, aryl, aryloxy, alkylidenyl or aralkylidenyl.

Heteroaryl-substituted pyrrole derivates, their preparation and their therapeutic uses

Compounds of formula (I): [wherein: A is a pyrrole ring; R1 is an optionally substituted phenyl or naphthyl group; R2 is an optionally substituted pyridyl or pyrimidinyl group; R3 represents a group of the formula -X-R4, wherein X is a single bond or an alkenylene group, and R4 is an optionally substituted nitrogen-containing heterocyclyl group; selected from the group consisting of 8-azabicyclo[3.2.1]octenyl, 9-azabicyclo[3.3.1]nonenyl and quinuclidinenyl groups, PROVIDED THAT said substituents R1 and R3 are bonded to the two atoms of said pyrrole ring which are adjacent to the atom of the pyrrole ring to which said substituent R2 is bonded] have excellent inhibitory activity against the production of inflammatory cytokines.

Imine intermediates for the preparation of trisubstituted imidazole compounds with multiple therapeutic properties

The invention relates to a novel group of iminc compounds and a process for their preparation, useful in the preparation of tri-substituted imadazoles having multiple therapeutic properties.