165821-75-0

Upstream product

• 165821-73-8 Toluene-4-sulfonic acid (R)-3-(3,4-dimethoxy-phenyl)-2-hydroxy-propyl ester 
• 165821-74-9 (R)-(-)-2-(3,4-dimethoxybenzyl)oxirane 
• 10313-60-7 3,4-dimethoxyphenylacetyl chloride 
• 2859-78-1 4-Bromoveratrole 
• 124-63-0 methanesulfonyl chloride 
• 165821-70-5 (S)-5-(3,4-dimethoxyphenyl)-4-hydroxypentanenitrile 
• 165821-68-1 5-(3,5-dimethoxyphenyl)-4-oxopentanenitrile 

Downstream Products

• 134454-21-0 (R)-2-(3,4-dimethoxybenzyl)-pyrrolidine 

Relevant academic research and scientific papers

Enantioselective synthesis of 2-substituted pyrrolidines from 4-hydroxynitriles. Application to the synthesis of the dopamine agonist RS-59022

Two novel routes to optically active 4-hydroxynitriles and the subsequent cyclization to 2-substituted pyrrolidines are described. The methodology is applied to the synthesis of the key intermediate used in the synthesis of the dopamine agonist RS-59022. Unusual selectivity in the CBS reduction of 4-oxonitriles is explained through structural and mechanistic analysis.