16585-04-9Relevant articles and documents
Synthesis of supposed enone prodrugs of apomorphine and N-propyl-norapomorphine
Liu, Danyang,Venhuis, Bastiaan J.,Wikstr?m, H?kan V.,Dijkstra, Durk
, p. 7264 - 7270 (2007)
We have previously demonstrated that the enone prodrug GMC-6650 acts as a highly efficient dopaminergic agonist. In vivo, this compound is bioactivated to its corresponding catecholamine, TL-334. The goal here was to investigate if this bioactivation also occurs for the supposed enone prodrug of apomorphine. We describe the 12-step synthesis of this supposed prodrug, 6-alkyl-5,6,6a,8,9,10-hexahydro-4H-dibenzo[de,g]quinolin-11(7H)-one (R=Me, n-Pr).