16585-04-9Relevant academic research and scientific papers
Synthesis of supposed enone prodrugs of apomorphine and N-propyl-norapomorphine
Liu, Danyang,Venhuis, Bastiaan J.,Wikstr?m, H?kan V.,Dijkstra, Durk
, p. 7264 - 7270 (2007)
We have previously demonstrated that the enone prodrug GMC-6650 acts as a highly efficient dopaminergic agonist. In vivo, this compound is bioactivated to its corresponding catecholamine, TL-334. The goal here was to investigate if this bioactivation also occurs for the supposed enone prodrug of apomorphine. We describe the 12-step synthesis of this supposed prodrug, 6-alkyl-5,6,6a,8,9,10-hexahydro-4H-dibenzo[de,g]quinolin-11(7H)-one (R=Me, n-Pr).
Enantioselective synthesis of chiral tetrahydroisoquinolines by iridium-catalyzed asymmetric hydrogenation of enamines
Yan, Pu-Cha,Xie, Jian-Hua,Hou, Guo-Hua,Wang, Li-Xin,Zhou, Qi-Lin
supporting information; experimental part, p. 3243 - 3250 (2010/04/24)
Chiral iridium complexes based on spiro phosphoramidite ligands are demonstrated to be highly efficient catalysts for the asymmetric hydrogenation of unfunctionalized enamines with an exocyclic double bond. In combination with excess iodine or potassium i
