50893-11-3

Basic information

• Product Name: N-Methyl-N-acetyl-2-phenylethanamine
• Synonyms: N-Methyl-N-acetyl-2-phenylethanamine;N-Methyl-N-phenethylacetamide
• CAS NO: 50893-11-3
• Molecular Formula: C₁₁H₁₅NO
• Molecular Weight: 177.24
• Mol File: 50893-11-3.mol

Chemical Properties

• Melting Point: 38-39 °C
• Boiling Point: 165-171 °C(Press: 12 Torr)
• Appearance: /
• Density: 1.006±0.06 g/cm3(Predicted)
• PKA: -0.50±0.70(Predicted)
• CAS DataBase Reference: N-Methyl-N-acetyl-2-phenylethanamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-Methyl-N-acetyl-2-phenylethanamine(50893-11-3)
• EPA Substance Registry System: N-Methyl-N-acetyl-2-phenylethanamine(50893-11-3)

Safety Data

• Hazardous Substances Data: 50893-11-3(Hazardous Substances Data)

Upstream product

• 108-24-7 acetic anhydride 
• 589-08-2 N-Methyl-N-phenethylamine 
• 1126-71-2 N,N-dimethylphenethylamine 
• 60-35-5 acetamide 
• 103-63-9 1-phenyl-2-bromoethane 
• 23069-99-0 N-(2-phenylethyl)formamide 

Downstream Products

• 63065-18-9 β--propionsaeure 
• 63065-19-0 γ--butansaeure 
• 16585-04-9 2-Methyl-1-methylen-1,2,3,4-tetrahydroisochinolin 
• 63065-21-4 γ--buttersaeure 

Relevant articles and documents

Amide Bond Formation Catalyzed by Recyclable Copper Nanoparticles Supported on Zeolite Y under Mild Conditions

A series of catalysts based on supported copper nanoparticles have been prepared and tested in the amide bond formation from tertiary amines and acid anhydrides, in the presence of tert-butyl hydroperoxide as an oxidant. Copper nanoparticles on zeolite Y (CuNPs/ZY) was found to be the most efficient catalyst for the synthesis of amides, working in acetonitrile as solvent, under ligand- and base-free conditions in air. The products were obtained in good to excellent yields and in short reaction times. The CuNPs/ZY system also exhibited higher catalytic activity than some commercially available copper and iron sources and it was reused in ten reaction cycles without any further pre-treatment. This methodology has been successfully scaled-up to a gram scale with no detriment to the yield.

Mn(II)-Catalyzed N -Acylation of Amines

A practical protocol has been developed here for the Mn(II)-catalyzed N -acylation of amines with high yields using N, N -dimethylformamide and other amides as the carbonyl source. The protocol is simple, does not require any acid, base, ligand, or other additives, and encompasses a broad substrate scope for primary, secondary, and heterocyclic amines.

Cobalt(II)-Catalyzed N-Acylation of Amines through a Transamidation Reaction

A practical protocol has been developed for a Co(OAc)2·4H2O-catalyzed transamidation reaction. The reaction gives high yields and uses N,N-dimethylformamide and other amides as carbonyl sources. The protocol is rapid and simple, and it does not require any acids, bases, ligands, or other additives. It works well for a wide range of primary, secondary, and heterocyclic amines.