165875-63-8Relevant academic research and scientific papers
Asymmetric reduction of 2-chloro-3-oxo esters by transfer hydrogenation
Bai, Jinjin,Miao, Shifeng,Wu, Yun,Zhang, Yawen
experimental part, p. 2476 - 2480 (2012/02/04)
Asymmetric reduction of 2-chloro-3-oxo esters was achieved by catalytic transfer hydrogenation using [RuCl2(p-cymene)](S,S)-TsDPEN as the chiral catalyst and HCOOH-Et3N as the hydrogen source. Moderate to good yields (up to 85%) and
Enantiodivergent, biocatalytic routes to both taxol side chain antipodes
Feske, Brent D.,Kaluzna, Iwona A.,Stewart, Jon D.
, p. 9654 - 9657 (2007/10/03)
Two enantiocomplementary bakers' yeast enzymes reduced an α-chloro-β-keto ester to yield precursors for both enantiomers of the N-benzoyl phenylisoserine Taxol side chain. After base-mediated ring closure of the chlorohydrin enantiomers, the epoxides were
A new enantioselective synthesis of glycidates via dynamic kinetic resolution of racemic 2-chloro-3-keto esters using chiral Ru (II) complexes
Genet, Jean-Pierre,Cano De Andrade,Ratovelomanana-Vidal
, p. 2063 - 2066 (2007/10/02)
2-chloro-3-keto esters were quantitatively hydrogenated to syn and anti 2-chloro-3-hydroxyester by asymmetric hydrogenation with chiral ruthenium (II) catalysts prepared in-situ from (COD)Ru(2-methylallyl)2 in presence of atropisomeric ligands such as MeO-Biphep and Binap, giving enantioselectivity up to 99%, 2-chloro-3-hydroxy esters were treated with different bases to give (E)-and (Z)-2,3-epoxyalkanoates in 65-90% yields with 84-97% ee.
