16595-99-6

Upstream product

• 455-14-1 4-trifluoromethylphenylamine 
• 122-51-0 orthoformic acid triethyl ester 
• 149-73-5 trimethyl orthoformate 

Downstream Products

• 1273415-25-0 Sn(CH(NC₆H₄CF₃)2)2 
• 253150-39-9 silver N,N'-di-(4-trifluoromethyl)phenylformamidinate 
• 130685-67-5 4-Cyan-3-(4-trifluormethyl-phenylamino)-benzo<4,5>thieno<2,3-c>pyridin-9,9-dioxid 

Relevant academic research and scientific papers

Near-Infrared Emission Induced by Shortened Pt-Pt Contact: Diplatinum(II) Complexes with Pyridyl Pyrimidinato Cyclometalates

Four diplatinum(II) complexes with the formula [Pt(pypm)(μ-Fn)]2 (2, 3a-c) bearing both a pyridine-pyrimidinate chelate and formamidinate bridge, where (pypm)H and FnH stand for 5-(pyridin-2-yl)-2-(trifluoromethyl)pyrimidi

Rational Design of Noncovalent Diamondoid Microporous Materials for Low-Energy Separation of C6-Hydrocarbons

Selective separation of gases/vapors with similar physicochemical properties involves energetically costly distillation processes. Alternative separation processes based on shape-selective molecular sieving, taking place on porous frameworks (or membranes

Ultrasound promoted expeditious, catalyst-free and solvent-free approach for the synthesis of N,N′-diarylsubstituted formamidines at room temperature

An effortless and efficient protocol was developed for the synthesis of N,N′-diarylsubstituted formamidines under environment-friendly conditions. Ultrasonic energy was employed to obtain the desired products in excellent yields with high purity under solvent-free and catalyst-free conditions. Products were purified by the crystallization technique to avoid excess utilization of organic solvents.

Multicomponent synthesis of 1-aryl 1,2,4-triazoles

A multicomponent (single reactor) process for the synthesis of 1-aryl 1,2,4-triazoles was explored and developed. This transformation prepared the 1,2,4-triazole directly from anilines, amino pyridines, and pyrimidines. The reaction scope was explored with 21 different substrates, and the position of the nitrogen atoms in the newly formed ring was established by 15N labeling and NMR spectroscopy.

Deep eutectic solvent promoted highly efficient synthesis of N, N'-diarylamidines and formamides

A deep eutectic solvent was used as a dual catalyst and reaction medium for the efficient N-formylation of aromatic amines without hazardous organic solvent and catalyst. Treatment of aromatic amines with trimethyl orthoformate and formic acid in deep eutectic solvent at 70 °C gives the corresponding N-formyl derivatives in good to excellent yields. This simple ammonium deep eutectic solvent, easily synthesized from choline chloride and SnCl2, with 100% atom economy and making it applicable to industry and laboratory. Furthermore, heating the trimethyl orthoformate and aromatic primary amines in the deep eutectic solvent results in formation of the corresponding N,N'-diarylamidines in high yields.

Intermolecular hydrogen-fluorine interaction in dimolybdenum triply bonded complexes modified by fluorinated formamidine ligands for the construction of 2D- and 3D-networks

The formamidines ArNHC(H)=N-Ar [Ar = Ph (2a), 4-F-Ph (2b), 3,5-F 2Ph (2c) and 2,6-F2Ph (2d) and R = 2,3,5-F3Ph (2e), 3,4,5-F3Ph (2f), F5Ph (2g) and 4-CF3Ph (2h)] were synthesized and the influence of the introduction of a fluorine or a trifluoromethyl group into the aryl unit on the solid-state structures was investigated. On comparing the experimental data, only marginal differences in the geometrical and electronic features of the diverse substituted species were detected. DFT calculations and X-ray crystallography of 2d-2g revealed that the E-syn-configuration corresponded to the thermodynamically most stable motif of all of the examined formamidines. However, in their solid-state, these ligands showed a range of H...F interactions, which varied depending on the number and position of the fluorine atoms on the aryl group and thus led to interesting solid-state structures. Moreover, compounds 2 were used for the synthesis of the new heteroleptic dimolybdenum triply-bonded complexes, Mo 2[(2a-2c; 2e-f)-H]2(OtBu)4 (3a-3c; 3e-3f). X-ray crystallography of complexes 3c and 3f revealed two different isomers in the solid state: in trans-3c the two formamidines are in one plane, while in cis-3c and cis-3f they are next to each other. The DFT calculations showed only a small distinction in energy between the configurations, which led us to assume that the different configurations were induced by the crystal packing. The specific H...F interactions provided by the different formamidines led to a two-dimensional arrangement for trans-3c and a three-dimensional network for cis-3c and cis-3f.