16599-32-9Relevant academic research and scientific papers
Fluorescent molecular sensing of amino acids bearing an aromatic residue
Fabbrizzi, Luigi,Licchelli, Maurizio,Perotti, Angelo,Poggi, Antonio,Rabaioli, Giuliano,Sacchi, Donatella,Taglietti, Angelo
, p. 2108 - 2113 (2001)
The tetra-amino tripodal ligand, 3, containing two anthracene subunits, has been prepared through a multi-step synthesis and its solution properties have been studied by potentiometric and spectrofluorimetric techniques. The zinc(II) complex, [ZnII/
Synthesis of polyheterocyclic pyrrolo[3,4-b]pyridin-5-ones via a one-pot (Ugi-3CR/aza diels-alder/N-acylation/aromatization/SN2) process. A suitable alternative towards novel Aza-analogues of falipamil
Zamudio-Medina, Angel,García-González, Ailyn N.,Herrera-Carrillo, Genesis K.,Zárate-Zárate, Daniel,Benavides-Macías, Adriana,Tamariz, Joaquín,Ibarra, Ilich A.,Islas-Jácome, Alejandro,González-Zamora, Eduardo
, (2018/04/06)
We describe the one-pot synthesis of twenty polyheterocyclic pyrrolo[3,4-b]pyridin-5-ones via a cascade process (Ugi-3CR/aza Diels-Alder/N-acylation/aromatization) in 20 to 95% overall yields, as well as four pharmacologically promising analogues via an improved cascade process (Ugi-3CR/aza Diels-Alder/N-acylation/aromatization/SN2): two piperazine-linked pyrrolo[3,4b]pyridin-5-ones in 33 and 34%, and a couple of Falipamil aza-analogues in 30 and 35% overall yields. It is worth highlighting the good substrate scope found, because final products are furnished with alkyl, aryl, and heterocyclic substituents. The use of chain-ring tautomerizable isocyanides (as key reagents for the Ugi-type three component reaction) allowed for a rapid and efficient assembly of the polysubstituted oxindoles, which were used in situ toward the complex products, conferring features like robustness, sustainability, and the one-pot approach to this synthetic methodology.
