1660132-26-2

Basic information

• Product Name: 2-(((bis(trimethylsilyl)methyl)dimethylsilyl)oxy)-N,N-diethylbenzamide
• CAS NO: 1660132-26-2
• Molecular Weight: 409.792
• Mol File: 1660132-26-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(((bis(trimethylsilyl)methyl)dimethylsilyl)oxy)-N,N-diethylbenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(((bis(trimethylsilyl)methyl)dimethylsilyl)oxy)-N,N-diethylbenzamide(1660132-26-2)
• EPA Substance Registry System: 2-(((bis(trimethylsilyl)methyl)dimethylsilyl)oxy)-N,N-diethylbenzamide(1660132-26-2)

Safety Data

• Hazardous Substances Data: 1660132-26-2(Hazardous Substances Data)

Upstream product

• 65009-00-9 O-phenyl N,N-diethylcarbamate 
• 108-95-2 phenol 
• 88-10-8 N,N-diethylcarbamyl chloride 
• 19311-91-2 N,N-diethylsalicylamide 
• 78907-55-8 Bis-(trimethylsilyl)-(dimethylchlorsilyl)-methan 

Relevant articles and documents

Lithiation of a silyl ether: Formation of an ortho-fries hydroxyketone

A hydroxy-directed alkylation of an N,N-diethylarylamide using CIPE-assisted α-silyl carbanions (CIPE=complex-induced proximity effect) has been developed using a simple reagent combination of LDA (lithium diisopropylamide) and chlorosilane. A study of the mechanism, and the application of the procedure to an anionic Snieckus-Fries rearrangement for a highly efficient synthesis of the potent phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002, are reported.