1660153-91-2 Usage
Reactions
Ligand for the Palladium-catalyzed Buchwald-Hartwig cross-coupling of hindered primary amines and aryl halides.
Uses
(t-Bu)PhCPhos is the Pd G3 complex, from the Buchwald group offers best-in-class performance in the arylation of sterically hindered primary amines.
Check Digit Verification of cas no
The CAS Registry Mumber 1660153-91-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,6,6,0,1,5 and 3 respectively; the second part has 2 digits, 9 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1660153-91:
(9*1)+(8*6)+(7*6)+(6*0)+(5*1)+(4*5)+(3*3)+(2*9)+(1*1)=152
152 % 10 = 2
So 1660153-91-2 is a valid CAS Registry Number.
1660153-91-2Relevant articles and documents
Rational ligand design for the arylation of hindered primary amines guided by reaction progress kinetic analysis
Ruiz-Castillo, Paula,Blackmond, Donna G.,Buchwald, Stephen L.
, p. 3085 - 3092 (2015)
We report the Pd-catalyzed arylation of very hindered α,α,α-trisubstituted primary amines. Kinetics-based mechanistic analysis and rational design have led to the development of two biarylphosphine ligands that allow the transformation to proceed with excellent efficiency. The process was effective in coupling a wide range of functionalized aryl and heteroaryl halides under mild conditions.
