2'-[(1,1-Dimethylethyl)phenylphosphino]-N2,N2,N6,N6-tetramethyl-[1,1'-biphenyl]-2,6-diamine

Base Information

• Chemical Name: 2'-[(1,1-Dimethylethyl)phenylphosphino]-N2,N2,N6,N6-tetramethyl-[1,1'-biphenyl]-2,6-diamine
• CAS No.: 1660153-91-2
• Molecular Formula: C26H33N2P
• Molecular Weight: 404.53
• Mol file: 1660153-91-2.mol

Synonyms:2'-[(1,1-Dimethylethyl)phenylphosphino]-N2,N2,N6,N6-tetramethyl-[1,1'-biphenyl]-2,6-diamine;2-(t-Butylphenylphosphino)-2',6'-dimethylamino-1,1'-biphenyl, 98% (t-Bu)PhCPhos

Chemical Property of 2'-[(1,1-Dimethylethyl)phenylphosphino]-N2,N2,N6,N6-tetramethyl-[1,1'-biphenyl]-2,6-diamine

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

2-(t-Butylphenylphosphino)-2',6'-dimethylamino-1,1'-biphenyl, 98% (t-Bu)PhCPhos ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: (t-Bu)PhCPhos is the Pd G3 complex, from the Buchwald group offers best-in-class performance in the arylation of sterically hindered primary amines.

Technology Process of 2'-[(1,1-Dimethylethyl)phenylphosphino]-N2,N2,N6,N6-tetramethyl-[1,1'-biphenyl]-2,6-diamine

There total 1 articles about 2'-[(1,1-Dimethylethyl)phenylphosphino]-N2,N2,N6,N6-tetramethyl-[1,1'-biphenyl]-2,6-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2'-bromo-N2,N2,N6,N6-tetramethyl-[1,1'-biphenyl]-2,6-diamine (1160556-63-7) + tert-butylchlorophenylphosphane (29949-69-7,146387-73-7,146387-74-8) → C26H33N2P (1660153-91-2)

Guidance literature:

2'-bromo-N²,N²,N⁶,N⁶-tetramethyl-[1,1'-biphenyl]-2,6-diamine; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 1h; Inert atmosphere;

tert-butylchlorophenylphosphane; With copper(l) chloride; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 6h; Inert atmosphere;

DOI:10.1021/ja512903g

Reference yield: 87.0%

bis[(trimethylsilyl)methyl](1,5-cyclooctadiene)palladium(II) (225931-80-6) + 4-bromobenzenecarbonitrile (623-00-7) + C26H33N2P (1660153-91-2) → C33H37BrN3PPd

Guidance literature:

In cyclohexane; at 20 ℃;

DOI:10.1021/ja512903g

Reference yield: 86.0%

(2'-amino-1,1'-biphenyl-2-yl)methanesulfonatopalladium(II) dimer (1435520-65-2) + C26H33N2P (1660153-91-2) → C39H46N3O3PPdS

Guidance literature:

In dichloromethane; at 20 ℃; for 3h;

DOI:10.1021/ja512903g

upstream raw materials:

2'-bromo-N²,N²,N⁶,N⁶-tetramethyl-[1,1'-biphenyl]-2,6-diamine

tert-butylchlorophenylphosphane