166046-62-4

Upstream product

• 70373-49-8 2-cyano-N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)acetamide 
• 83-07-8 4-amino-2,3-dimethyl-1-phenylpyrazolin-5-one 
• 109-77-3 malononitrile 
• 2826-26-8 2-(4-methoxyphenylmethylene)malononitrile 

Downstream Products

• 953817-53-3 C₂₇H₂₂N₆O₄ 
• 953817-54-4 C₂₇H₂₂N₆O₄ 
• 953817-52-2 C₂₅H₂₁N₇O₃ 

Relevant academic research and scientific papers

A convenient route to pyridones, pyrazolo[2,3-a]pyrimidines and pyrazolo[5,1-c]triazines incorporating antipyrine moiety

Condensation of 4-aminoantipyrine with ethyl acetoacetate, ethyl benzoylacetate, and ethyl cyanoacetate furnished the corresponding ethyl 3-(1,2-dihydro-1,5-dimethyl-2-phenyl-3-oxo-3H-pyrazol-4-yl)aminoacrylate and 2-cyano-N-[(1,2-dihydro-1,5-dimethyl-2-p

Synthesis of novel 1-pyrazolylpyridin-2-ones as potential anti-inflammatory and analgesic agents

A new series of 4-alkyl/aryl-2-oxo-1-pyrazolyl-1,2-dihydropyridine-3- carbonitriles, pyrazolo[3,4-b]pyridine-5-carbonitriles and pyrido[2,3-d] pyrimidine-6-carbonitriles have been synthesized and tested for their anti-inflammatory and analgesic activities. Among the tested compounds, 3e and 8b exhibited comparable anti-inflammatory activity to the standard (indomethacin). Compounds 5, 7a, and 8b displayed potent analgesic activity. Detailed syntheses, spectroscopic and biological data are reported.