166049-87-2Relevant academic research and scientific papers
New route to aminomethylphosphonic acid via bis(trifluoroethyl) phosphonate transesterification
Berte-Verrando, Sylvie,Diziere, Rachel,Samadi, Mohammad,Savignac, Philippe
, p. 3125 - 3128 (1995)
Transesterification of bis(trifluoroethyl) chloromethyl- and azidomethyl-phosphonates with alcohols in the presence of catalytic quantities of alcoholates gives dialkyl chloromethyl- and azidomethyl-phosphonates in good yield.This process has been used fo
Mild synthesis of organophosphorus compounds: Reaction of phosphorus-containing carbenoids with organoboranes
Antczak, Monika I.,Montchamp, Jean-Luc
supporting information; experimental part, p. 977 - 980 (2009/04/10)
Organoboranes react with phosphorus-containing carbenoids to produce a variety of functionalized organophosphorus compounds under mild conditions. In some cases, selective migration of one group atached to boron can be observed. Phosphonite-borane complexes are introduced as novel synthons for the synthesis of phosphinic esters.
Direct α-chlorination of O,O-dialkyl chalcogenophosphonates with phosphorus oxychloride
Mons, Stéphane,Sabourault, Nicolas,Klein, Emmanuel,Mioskowski, Charles,Lebeau, Luc
, p. 7547 - 7549 (2007/10/03)
α-Chlorination of phosphonates, and O,O-dialkyl thio- and selenophosphonates involving the direct reaction of their lithiated anion with phosphorus oxychloride is described. The reaction gives good results where previously known methods fail. The role of the chalcogen atom, and the influence of the nature of the alkyl chain with respect to the reactivity are discussed.
First Use of Benzyl Phosphites in the Michaelis-Arbuzov Reaction Synthesis of Mono-, Di-, and Triphosphate Analogs
Saady, Mourad,Lebeau, Luc,Mioskowski, Charles
, p. 670 - 678 (2007/10/02)
Benzyl phosphites were used in the Michaelis-Arbuzov reaction.Special experimental conditions allowed preparation of a set of phosphonate analogs of mono-, di-, and triphosphate.Furthermore, regioselective mono-deprotection mades these molecules useful building blocks for the synthesis of analogs of polyphosphorylated compounds of biological interest (e.g. nucleotides), after removal of all phosphonate benzyl ester groups under very mild conditions and high yields.
