166049-85-0

Basic information

• Product Name: methylenebisphosphonic acid tribenzyl methyl ester
• Synonyms: methylenebisphosphonic acid tribenzyl methyl ester
• CAS NO: 166049-85-0
• Molecular Weight: 460.403
• Mol File: 166049-85-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: methylenebisphosphonic acid tribenzyl methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: methylenebisphosphonic acid tribenzyl methyl ester(166049-85-0)
• EPA Substance Registry System: methylenebisphosphonic acid tribenzyl methyl ester(166049-85-0)

Safety Data

• Hazardous Substances Data: 166049-85-0(Hazardous Substances Data)

Upstream product

• 710-09-8 methyl-phosphonic acid benzyl methyl ester 
• 538-37-4 dibenzyl phosphochloridate 
• 166049-87-2 dibenzyl (chloromethyl)phosphonate 
• 113138-09-3 Phosphorous acid dibenzyl ester methyl ester 

Downstream Products

• 503306-26-1 difluoromethylenebisphosphonic acid tribenzyl methyl ester 
• 7292-39-9 <methyl>phosphonic acid monobenzyl ester 

Relevant articles and documents

Synthesis of Di- and Triphosphate Ester Analogs via a Modified Michaelis-Arbuzov Reaction

For the first time, benzyl phosphites allowed the preparation of a set of polyphosphonates from chloromethyl halides via the Michaelis-Arbuzov reaction performed under vacuum.Regioselective mono-deprotection or complete deprotection of these phosphonates provide useful building blocks for the synthesis of biological phosphate analogs.

First Use of Benzyl Phosphites in the Michaelis-Arbuzov Reaction Synthesis of Mono-, Di-, and Triphosphate Analogs

Benzyl phosphites were used in the Michaelis-Arbuzov reaction.Special experimental conditions allowed preparation of a set of phosphonate analogs of mono-, di-, and triphosphate.Furthermore, regioselective mono-deprotection mades these molecules useful building blocks for the synthesis of analogs of polyphosphorylated compounds of biological interest (e.g. nucleotides), after removal of all phosphonate benzyl ester groups under very mild conditions and high yields.