16610-51-8

Usage

Uses

Used in Synthetic Chemistry:
P4S10-Pyridine complex is used as a thionating agent for [application reason] in synthetic chemistry. This complex plays a crucial role in the synthesis of various organic and inorganic compounds, facilitating the formation of thioether linkages and enhancing the overall efficiency of the chemical reactions.
Used in Pharmaceutical Industry:
P4S10-Pyridine complex is used as a [application type] for [application reason] in the pharmaceutical industry. Its unique properties make it a valuable tool in the development of new drugs and therapeutic agents, potentially leading to breakthroughs in the treatment of various diseases and medical conditions.
Used in Material Science:
P4S10-Pyridine complex is used as a [application type] for [application reason] in material science. Its unique chemical structure and properties can be harnessed to create novel materials with enhanced properties, such as improved conductivity, stability, or reactivity.

Upstream product

• 110-86-1 pyridine 

Downstream Products

• 1438851-60-5 methyl N-{(2R,3R)-3-[(2S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl]-3-methoxy-2-methylpropanethioyl}-L-phenylalaninate 

Relevant academic research and scientific papers

Facile synthesis of novel 6-methyl-5-phenyl-2-sulfido-1,2,3,5-tetrahydro-4H[1,2] oxazolo[4′,5′:5,6]pyrano[2,3-d][1,3,2]diazaphosphinines

A number of 6-methyl-5-phenyl-2-sulfido-1,2,3,5-tetrahydro-4H[1,2]oxazolo[4′,5′: 5,6]pyrano[2,3-d][1,3,2]diazaphosphinines 4–11 were synthesized via an interaction of tetraphosphorus decasulfide and Lawesson’s reagent under different conditions with 6-amino-3-methyl-4-phenyl-4H-pyrano[3,2-d][1,2]oxazole-5-carbonitrile (3). The reaction mechanisms for these products were discussed. Structures of the newly synthesized products were established on the basis of elemental analysis and spectral data.

Reaction of 2-imino-2H-chromene-3-carboxamide with phosphorus sulfides: Synthesis of novel 2-sulfido-2,3-dihydro-4H-chromeno[2,3-d][1,3,2]diaza-phosphinines

Novel 2-sulfido-2,3-dihydro-4H-chromeno[2,3-d][1,3,2]diazaphosphinines are obtained in a simple one-pot procedure via treatment of 2-imino-2H-chromene-3-carboxamide with various phosphorus sulfides. Possible reaction mechanisms are proposed. The structure

New acyclic neutral phosphorus sulfides and sulfide oxides

A great number of binary neutral phosphorus sulfides was discovered and investigated. However all stable representatives of this family of compounds adopt a polycyclic structure in contrast to their lighter homologues, the nitrogen oxides. Acyclic representatives can be stabilized by adduct formation with a nitrogen base. The bis(pyridine) adduct py2P2S 5 of the unstable acyclic phosphorus sulfide P2S 5 is readily obtained stirring P4S10 in pyridine at ambient temperature. X-ray diffraction studies on single crystals of py2P2S5·0.5 py (1b) show a N 2O5 like structure for the P2S5 framework. The long P-N distances of 1.86 A indicate only weak coordination of the pyridine molecules to phosphorus. Single crystal X-ray diffraction studies on py2P2S4.34O 0.66 (2) reveal the presence of py2P2S 4O (3) together with py2P2S5 in the crystal. Compound 3 contains the mixed phosphorus oxide sulfide molecule P 2S4O stabilized as bis(pyridine) adduct. It is readily obtained from pyP2S5 by oxidation with KMnO4 in pyridine. The oxygen atom occupies the bridging position between the two phosphorus atoms. Quantum chemical calculations at the MPW1PW91 level of theory as well as DTA/TG thermal analyses confirm the weak coordination of the pyridine molecules in py2P2S5, py2P 2S4O, and py2P2S7 to phosphorus.

Unexpected Result of Thiophosphorylation of 6-Aminopyrano[2,3-c]pyrazole-5-carbonitrile Derivative

The reaction of 6-amino-3-methyl-4-(2,4-dichlorophenyl)-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile with phosphorus sulfide in boiling pyridine unexpectedly leads to the formation of a not previously described heterocyclic system—[1,2]oxaphosphinino[6

CYTOTOXIC PEPTIDES AND ANTIBODY DRUG CONJUGATES THEREOF

The present invention is directed to cytotoxic pentapeptides, to antibody drug conjugates thereof, and to methods for using the same to treat cancer.

A THIONATION PROCESS AND A THIONATING AGENT

A process for transforming a group >C=O (I) in a compound into a group >C=S (II) or into a tautomeric form of group (II) in a reaction giving a thionated reaction product, by use of crystalline P2S5·2 C5H5N as a thionating agent. A thionating agent which is crystalline P2S5·2 C5H5N

Thionations using a P4S10-pyridine complex in solvents such as acetonitrile and dimethyl sulfone

Tetraphosphorus decasulfide (P4S10) in pyridine has been used as a thionating agent for a long period of time. The moisture-sensitive reagent has now been isolated in crystalline form, and the detailed structure has been determined by X-ray crystallography. The thionating power of this storable reagent has been studied and transferred to solvents such as acetonitrile in which it has proven to be synthetically useful and exceptionally selective. Its properties have been compared with the so-called Lawesson reagent (LR). Particularly interesting are the results from thionations at relatively high temperatures (165 °C) in dimethyl sulfone as solvent. Under these conditions, for instance, acridone and 3-acetylindole could quickly be transformed to the corresponding thionated derivatives. Glycylglycine similarly gave piperazinedithione. At these temperatures, LR is inefficient due to rapid decomposition. The thionated products are generally cleaner and more easy to obtain because in the crystalline reagent, impurities which invariably are present in the conventional reagents, P4S 10 in pyridine or LR, have been removed. 2011 American Chemical Society.