16611-97-5Relevant academic research and scientific papers
A simple Lewis acid induced reaction of phenols with electrophiles: Synthesis of functionalized 4H-chromenes and ortho-benzylphenols
Sreenivasulu, Chinnabattigalla,Thadathil, Ditto Abraham,Pal, Sumit,Gedu, Satyanarayana
, p. 112 - 122 (2020)
Lewis acid ZnCl2 promoted cyclization protocol to 4H-chromenes is accomplished, using readily available phenols and acetophenones as starting materials. Interestingly, the process is feasible under the solvent free environment. Synthesis of a variety of 4H-chromenes have been accomplished using this strategy. In addition, this concept is extended to the synthesis of ortho-benzylphenols by treating phenols either with styrenes or secondary benzylic alcohols.
