166167-94-8

Upstream product

• 69555-14-2 ethyl N-diphenylmethylene glycine 
• 17201-43-3 4-cyanobenzyl bromide 
• 214842-20-3 2-(Benzhydrylidene-amino)-3-(4-cyano-phenyl)-propionic acid ethyl ester 

Downstream Products

• 18910-26-4 2-amino-3-(4-cyano-phenyl)-propionic acid 
• 214842-50-9 2-[2-(4-Thiocarbamoyl-benzenesulfonylamino)-acetylamino]-3-(4-thiocarbamoyl-phenyl)-propionic acid ethyl ester 
• 214842-37-2 2-[2-(4-Cyano-benzenesulfonylamino)-acetylamino]-3-(4-cyano-phenyl)-propionic acid ethyl ester 

Relevant academic research and scientific papers

12-EPI PLEUROMUTILINS

A compound selected from 14-O-[((Alkyl-, cycloalkyl-, heterocycloalkyl-, heteoroaryl-, or aryl)-sulfanyl)-acetyl]-12-epi-mutilins, or 14-O-[((Alkyl-, cycloalkyl-, heterocycloalkyl-, heteoroaryl-, or aryl)-oxy)-acetyl]-12-epi-mutilins, wherein 12-epi-mutilin is characterized in that the mutilin ring at position 12 is substituted by two substituents, the first substituent at position 12 of the mutilin ring is a methyl group which methyl group has the inverse stereochemistry compared with the stereochemistry of the methyl group at position 12 of the naturally occurring pleuromutilin ring, the second substituent at position 12 of the mutilin ring is a hydrocarbon group comprising at least one nitrogen atom and all other substituents of the mutilin ring having the same stereochemistry compared with the stereochemistry of the substituents at the corresponding positions in the naturally occurring pleuromutilin ring; optionally in the form of a salt and/or solvate, wherein the naturally occurring pleuromutilin is of formula processes for the preparation of such compounds and their use as pharmaceuticals.

Iron-catalyzed oxidative C - H/C - H cross-coupling: An efficient route to α-quaternary α-amino acid derivatives

Fully loaded: A coordinating activation strategy has been developed to furnish α-quaternary α-amino acids through the iron(III)-catalyzed oxidative functionalization of α-C(sp3) - H bonds of α-tertiary α-amino acid esters. The reaction exhibits a broad substrate scope for both α-amino acids and nucleophiles (Nu) as well as good functional-group tolerance (see scheme, DTBP=di-tert-butyl peroxide, DCE=1,2-dichloroethane). Copyright

Design of benzamidine-type inhibitors of factor Xa

A series of derivatives of rac-benzenesulfonyl-glycyl-phenylalanine or its ethyl ester with a combination of thioamido/amidino or amidino/amidino substituents in the benzene rings was synthesized as potential inhibitors of factor Xa (fXa). Among these, th