166179-47-1Relevant academic research and scientific papers
4-[(4-methylphenyl)sulfonyl]-1-(triphenylphosphoranylidene)-2- butanone and its dianion as versatile tools in organic synthesis
Barco, Achille,Benetti, Simonetta,De Risi, Carmela,Marchetti, Paolo,Pollini, Gian P.,Zanirato, Vinicio
, p. 1973 - 1976 (2007/10/03)
The title compound and the corresponding dianion have been used as convenient precursors for substituted divinyl ketones in both carbo- and heterocyclization reactions in a one-pot three-step sequence leading to substituted carbo- and heterocyclic ring systems and for the construction of the 4-keto-2-alkenoate subunit, a common structural feature of a variety of natural compounds, respectively.
A practical enantioselective synthesis of Epibatidine
Szantay, Csaba,Kardos-Balogh, Zsuzsanna,Moldvai, Istvan,Szantay Jr., Csaba,Temesvari-Major, Eszter,Blasko, Gabor
, p. 11053 - 11062 (2007/10/03)
Two different syntheses of Epibatidine (1) were designed and carried out using easily accessible reagents and convenient reaction conditions. The ring closure of the prochiral precursor 4 catalyzed by optically active α-phenyl-ethyl-amine gave the key intermediate 5 in over 80% ee from which the natural product (-)-1 has been prepared.
Epi-epibatidine derivatives, a process and intermediates for preparing them and epi-epibatidine and medicaments containing the epi-epibatidine derivatives and/or epi-epibatidine and the use of them
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, (2008/06/13)
The subject-matter of the invention are epi-epibatidine derivatives of general formula wherein Rstands for a C1 4-alkyl, C2 4-alkenyl, C2 4-alkinyl, C3 7-cycloalkyl, a
Process for preparing epibatidine
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, (2008/06/13)
The subject-matter of the invention is a process for preparing racemic or optically active epibatidine of formula which comprises subjecting racemic or optically active epi-epibatidine of formula to epimerization in the presence of a base or cyclising a 1
