166193-98-2Relevant academic research and scientific papers
Synthesis and biological evaluation of new cytotoxic indazolo[4,3-gh] isoquinolinone derivatives
Shahabi, Manochehr,Schirmer, Eva,Shanab, Karem,Leepasert, Theerachart,Ruzicka, Jana,Holzer, Wolfgang,Spreitzer, Helmut,Aicher, Babette,Schmidt, Peter,Blumenstein, Lars,Müller, Gilbert,Günther, Eckhard
, p. 1846 - 1852 (2013/04/10)
A series of indazolo[4,3-gh]isoquinolinones derivatives have been synthesized to decrease cardiotoxic side effects in comparison to Mitoxantrone. The antiproliferative effects of different side chains were investigated and tested on at least four different cell lines of cervix, ovarian, CNS, NSCLC (non-small-cell lung cancer) and colon carcinoma. In addition to antiproliferative activities, influence on cell cycle and intercalation behavior have been tested.
AZABENZIMIDAZOLES AS RESPIRATORY SYNCYTIAL VIRUS ANTIVIRAL AGENTS
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Page/Page column 21, (2012/06/30)
A compound satisfying formula I, a prodrug, N-oxide, addition salt, quaternary metal complex, or a stereochemically isomeric form thereof; (formula I) compositions contain these compounds as active ingredient and processes for preparing these compounds and compositions.
Design, synthesis and evaluation of novel uracil acetamide derivatives as potential inhibitors of Plasmodium falciparum dUTP nucleotidohydrolase
McCarthy, Orla,Musso-Buendia, Alex,Kaiser, Marcel,Brun, Reto,Ruiz-Perez, Luis M.,Johansson, Nils Gunnar,Pacanowska, Dolores Gonzalez,Gilbert, Ian H.
experimental part, p. 678 - 688 (2009/09/27)
The ubiquitous enzyme dUTP nucleotidohydrolase (dUTPase) catalyses the hydrolysis of dUTP to dUMP and can be considered as the first line of defence against incorporation of uracil into DNA. Inhibition of this enzyme results in over-incorporation of uraci
Synthesis of a metabolite of an anti-angiogenic lead candidate based on a d-glucosamine motif
Singh, Latika,Lam, Ann,Premraj, Rajaratnam,Seifert, Joachim
, p. 4854 - 4856 (2008/09/21)
A rapid synthetic access to ACL 21269 was established in 12 steps starting from thiogylcoside 9 utilizing synthons 8 and 6 to introduce the pharmacophores at positions 1 and 2. The functional groups decorating the glucosamine scaffold were introduced in a particular order and common protecting groups were employed to establish a robust synthetic process.
Synthesis and Biochemical Evaluation of Adenosylspermidine, a Nucleoside-Polyamine Adduct Inhibitor of Spermidine Synthase
Lakanen, John R.,Pegg, Anthony E.,Coward, James K.
, p. 2714 - 2727 (2007/10/03)
The synthesis of a new class of multisubstrate adduct inhibitors of polyamine biosynthesis has been investigated.The first target compound, designed to inhibit spermidine synthase, was obtained and proved to be a very potent inhibitor of that enzyme.Two s
