1662-22-2

Usage

Structure

Benzimidazole derivative with two fluorine atoms and a methyl group attached to the carbon atoms of the benzene ring

Potential applications

Medicinal chemistry and drug development

Possible uses

Synthesis of new pharmaceutical compounds or as a building block for the creation of biologically active molecules

Need for further research

To explore the full potential and properties of 1H-Benzimidazole,5,6-difluoro-2-methyl-(9CI).

Upstream product

• 76179-40-3 2-amino-4,5-difluoroaniline 
• 64-19-7 acetic acid 

Downstream Products

• 1782970-28-8 6-(5,6-difluoro-2-methyl-1H-benzimidazol-1-yl)-N-[4-(trifluoromethyl)phenyl]pyrazin-2-amine 

Relevant academic research and scientific papers

Simple inorganic base promoted C-N and C-C formation: synthesis of benzo[4,5]imidazo[1,2-a]pyridines as functional AIEgens used for detecting picric acid

Metal-free catalyzed intermolecular tandem Michael addition/cyclization has been developed for the synthesis of benzo[4,5]imidazo[1,2-a]pyridines from α-bromocinnamaldehyde and 2-substituted benzimidazoles. The reaction promoted by a simple inorganic base displays moderate to good yields and good functional group tolerance. The optical properties of some typical products have been investigated. We found that, due to the presence of the benzene ring at the C1-position of benzo[4,5]imidazo[1,2-a]pyridines which restricts intramolecular motion, as a new type of aggregation-induced emission (AIE) luminogen (AIEgen), they show very good solid-state fluorescence with quantum yields up to 88.80%. Importantly, the AIE performance of compound3bcan be useful to detect the nitroaromatic explosive picric acid (PA) with a detection limit and quenching constant of 42.5 nM and 7.27 × 104M?M, respectively.

SUBSTITUTED PYRIDINE AND PYRAZINE BMI-1 INHIBITORS

Amine substituted pyridine and pyrazine compounds and forms thereof that inhibit the function and reduce the level of B -cell specific Moloney murine leukemia virus integration site 1 (Bmi-1) protein and methods for their use to inhibit Bmi-1 function and reduce the level of Bmi-1 to treat a cancer mediated by Bmi-1 are described herein.