16623-03-3

Basic information

• Product Name: Cyclohexanone, 4-(1,1-dimethylethyl)-2,6-bis(phenylmethylene)-
• CAS NO: 16623-03-3
• Molecular Formula: C24H26O
• Molecular Weight: 330.47
• Mol File: 16623-03-3.mol

Chemical Properties

• CAS DataBase Reference: Cyclohexanone, 4-(1,1-dimethylethyl)-2,6-bis(phenylmethylene)-(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclohexanone, 4-(1,1-dimethylethyl)-2,6-bis(phenylmethylene)-(16623-03-3)
• EPA Substance Registry System: Cyclohexanone, 4-(1,1-dimethylethyl)-2,6-bis(phenylmethylene)-(16623-03-3)

Safety Data

• Hazardous Substances Data: 16623-03-3(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 
• 98-53-3 4-tercbutyl-cyclohexanone 

Downstream Products

• 18013-01-9 5-tert-Butyl-dihydropyrogallol 

Relevant articles and documents

Stereoelectronic Effects: Perlin Effects in Thiane-Derived Compounds

Stereoelectronic effects in thianes and thiane-derived sulfoxides, sulfones, sulfilimines, and sulfoximines were investigated by measuring 1JC,H coupling constants and by identification of normal and reversed Perlin effects, i.e., of differences in the coupling constants for equatorial and axial C–H bonds in the methylene groups of six-membered rings. The Perlin effects were correlated with results from natural bond orbital (NBO) analyses. NMR experiments were performed with conformationally restricted dimethyl- or tert-butyl-substituted derivatives, while the parent compounds were used for calculations. It turned out that the coupling constants are not only strongly influenced by stereoelectronic interactions with antiperiplanar C–H, C–C, C–O, and C–N bonds, but by the s character of the respective C–H bonds' carbon orbital as well.

Synthesis, characterization, biological evaluation and docking of some novel substituted 1, 3-thiazine derivatives

Objective: Chalcones and their heterocyclic analogs represent an important class of small molecules which have a wide range of pharmacological activities. Therefore, in this study, synthesis and anticonvulsant and antimicrobial activities of some new 1, 3

Synthesis, characterization, and crystal structures of α, α'-bis(substituted-benzylidene)cycloalkanone derivatives by nano-TiO2/HOAc

A new and economical synthesis of α, α'-bis(substituted-benzylidene)cycloalkanones has been achieved by the reaction of cycloalkanones with different aromatic aldehydes using nano-TiO2/acetic acid as a catalyst in ethanol under reflux conditions with excellent yields. Five new products and three new single crystal structures are reported.

Nanomagnetic-supported Sulfonic Acid: Simple and Rapid Method for the Synthesis of α,α′-Bis-(substituted-benzylidene) Cycloalkanones

Nanomagnetic-supported sulfonic acid is found to be a powerful and reusable heterogeneous catalyst for the rapid synthesis of α,α′-bis-(substituted-benzylidene)cycloalkanones under conventional heating and solvent free conditions. High yield, simple work up and easy recovery of the catalyst are the most obvious advantages of this procedure. In this paper, an efficient, sustainable and green procedure for synthesis of α,′α-bis-(substituted-benzylidene) cycloalkanones has been developed using a magnetically separable and easily recyclable nano-γ-Fe2O3-SO3H catalyst in solvent free medium under thermal condition. Easy magnetic separation of the catalyst eliminates the requirement of catalyst filtration after completion of the reaction which is an additional greener attribute of this method.

2-Heterocyclicalkyl-3,3a,4,5,6,7-hexahydro-3-phenyl-7-(phenylmethylene)-2H-indazoles

Compounds of the formula STR1 wherein R, X1, X2, A and B are as defined herein, and their N-oxides and acid addition salts thereof, are provided which have been found to possess anti-inflammatory activity. In addition, methods for preparing such compounds, pharmaceutical compositions containing such compounds, and methods for using such compositions as anti-inflammatory agents are also provided.