166249-00-9

Downstream Products

• 166249-01-0 Benzoic acid (2R,3R,5S)-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-5-trityloxymethyl-tetrahydro-thiophen-3-yl ester 
• 166249-02-1 Benzoic acid (2R,3R,5S)-2-[3-(2-methoxy-ethoxymethyl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-5-trityloxymethyl-tetrahydro-thiophen-3-yl ester 
• 166249-09-8 1-((2R,3R,5S)-3-Fluoro-5-trityloxymethyl-tetrahydro-thiophen-2-yl)-3-(2-methoxy-ethoxymethyl)-1H-pyrimidine-2,4-dione 
• 166249-08-7 1-(5-O-trityl-3-deoxy-4-thio-β-D-erythro-pentofuranosyl)-3-(2-methoxyethoxymethyl)uracil 
• 165399-43-9 1-((2R,3S,5S)-3-Fluoro-5-trityloxymethyl-tetrahydro-thiophen-2-yl)-1H-pyrimidine-2,4-dione 
• 165399-48-4 1-(5-O-trityl-3-deoxy-4-thio-β-D-threo-pentofuranosyl)uracil 

Relevant academic research and scientific papers

Unanticipated retention of configuration in the DAST fluorination of deoxy-4′-thiopyrimidine nucleosides with "up" hydroxyl groups

Fluorination of 1-(5-O-trityl-3-deoxy-4-thio-β-D-threo-pentofuranosyl)uracil (17) and 1-(5-O-trityl-2-deoxy-4-thio-β-D-threo- pentofuranosyl)uracil (20) with DAST proceeded with exclusive retention of configuration. The structures of the products were con