166264-58-0Relevant articles and documents
Incorporation of the bioactive moiety of leinamycin into thymidine
Szilágyi, ákos,Pelyvás, István F.,Majercsik, Orsolya,Herczegh, Pál
, p. 4307 - 4309 (2004)
A simple synthesis of 1,2-dithiolan-3-ones from α,β-unsaturated thiophenyl esters has been elaborated. With the aim of introducing the biologically active 1,2-dithiolan-3-one-1-oxide moiety of leinamycin into a nucleoside, the method was successfully appl
Conjugate reduction and reductive aldol cyclization of α,β- unsaturated thioesters catalyzed by (BDP)CuH
Li, Ninglin,Ou, Jun,Miesch, Michel,Chiu, Pauline
supporting information; experimental part, p. 6143 - 6147 (2011/10/08)
A conjugate reduction of α,β-unsaturated thioesters catalyzed by copper hydride using PMHS as stoichiometric reductant has been developed. 1,2-Bis(diphenylphosphino)benzene (BDP) was the most effective ligand for this reduction. Saturated thioesters could be produced in excellent yields when the substituent on the thiol is not sterically-demanding. This protocol was applied to induce the reductive aldol cyclization of keto-enethioates, which could offer β-hydroxythioesters in moderate to good yields.
Meyer-Schuster Rearrangement of γ-Sulfur-Substituted Propargyl Alcohols: A Convenient Synthesis of α,β-Unsaturated Thioesters
Yoshimatsu, Mitsuhiro,Naito, Motoyo,Kawahigashi, Masataka,Shimizu, Hiroshi,Kataoka, Tadashi
, p. 4798 - 4802 (2007/10/02)
γ-Sulfur-substituted propargyl alcohols 1a-e and 1ij reacted with polyphosphoric acid trimethylsilyl ester (PPSE) to give the α,β-unsaturated thioesters 3a-e and 3ij in good yields.However, the reactions of 3,3-dibutyl-1-(phenylthio)propargyl alcohol (1k) and 1-(phenylthio)ethynyl-1-cycloalkanols 1l-n with PPSE gave the enyne sulfides 2k-n exclusively.
