166266-19-9

Basic information

• Product Name: 5-Iodo-3-methyl-2-pyridinamine
• Synonyms: 2-amino-3-methyl-5-iodopyridine;5-Iodo-3-methylpyridin-2-amine, 2-Amino-5-iodo-3-picoline;2-AMINO-3-METHYL-5-IODOPYRIDINE 98%;5-iodo-3-methyl-2-pyridinylamine;5-iodo-3-methyl-2-pyridinamine (en);(5-iodo-3-methyl-2-pyridyl)amine;2-AMINO-5-IODO-3-METHYLPYRIDINE;2-AMINO-5-IODO-3-PICOLINE
• CAS NO: 166266-19-9
• Molecular Formula: C₆H₇IN₂
• Molecular Weight: 234.04
• Product Categories: Pyridine;Pyridines;Boronic Acid;Heterocycle-Pyridine series;amine| alkyl Iodine
• Mol File: 166266-19-9.mol
• Article Data: 5

Chemical Properties

• Melting Point: 110.2-110.5°C
• Boiling Point: 303.4 °C at 760 mmHg
• Flash Point: 137.3 °C
• Appearance: /
• Density: 1.898 g/cm³
• Vapor Pressure: 0.000935mmHg at 25°C
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility: soluble in Methanol
• PKA: 5.22±0.49(Predicted)
• Sensitive: Light Sensitive
• CAS DataBase Reference: 5-Iodo-3-methyl-2-pyridinamine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Iodo-3-methyl-2-pyridinamine(166266-19-9)
• EPA Substance Registry System: 5-Iodo-3-methyl-2-pyridinamine(166266-19-9)

Safety Data

• Hazard Codes: Xi
• Statements: 41
• Safety Statements: 26-39
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 166266-19-9(Hazardous Substances Data)

Usage

General Description

5-Iodo-3-methyl-2-pyridinamine is a chemical compound with the molecular formula C6H6IN3. It is a derivative of pyridine, containing an iodine atom and a methyl group attached to the 3 and 2 positions of the pyridine ring, respectively. 5-Iodo-3-methyl-2-pyridinamine is used in the synthesis of pharmaceuticals and agrochemicals, and has potential applications in the field of medicinal chemistry. Its chemical structure and properties make it suitable for use as a building block in the development of new drugs and agricultural chemicals. Additionally, 5-Iodo-3-methyl-2-pyridinamine may also have other industrial and research applications, making it a versatile compound with useful properties.

InChI:InChI=1/C6H7IN2/c1-4-2-5(7)3-9-6(4)8/h2-3H,1H3,(H2,8,9)/p+1

Upstream product

• 3430-21-5 5-bromo-3-methyl-pyridin-2-ylamine 
• 1603-40-3 3-methylpyridin-2-ylamine 

Downstream Products

• 930121-92-9 3-methyl-5-(4-(trifluoromethyl)phenyl)pyridin-2-amine 
• 1450622-39-5 2-(2-(4-((6-amino-5-methyl-3-pyridinyl)sulfonyl)phenyl)-5-pyrimidinyl)-1,1,1-trifluoro-2-propanol 
• 1450622-42-0 3-methyl-5-((4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)sulfonyl)-2-pyridinamine 
• 1450622-41-9 5-((4-bromophenyl)sulfonyl)-3-methyl-2-pyridinamine 
• 1450622-40-8 5-((4-bromophenyl)sulfanyl)-3-methyl-2-pyridinamine 
• 1386977-28-1 (S)-3-(6-amino-5-methylpyridin-3-yl)-4-benzyl-5,5-diphenyloxazolidin-2-one 
• 59782-89-7 2-Chloro-5-iodo-3-methylpyridine 
• 166266-21-3 2-Benzyloxy-5-<3'-<<(1,1-dimethylethyl)diphenylsilyl>oxy>-β-D-glycero-pentofuran-3'-ulos-1'-yl>-3-methylpyridine 
• 166266-27-9 2-(Benzyloxy)-5-(2'-deoxy-β-O-ribofuranosyl)-3-methylpyridine 
• 166266-20-2 2-(Benzyloxy)-5-iodo-3-methylpyridine 
• 289681-53-4 2-[2-(4-nitrophenyl)ethoxy]-5-[5'-O-(4,4'-dimethoxytrityl)-1',2'-dideoxy-β-D-erythro-pentafuranozyl]-3-methylpyridine 
• 289681-50-1 ((2R,5R)-3-(tert-Butyl-diphenyl-silanyloxy)-5-{5-methyl-6-[2-(4-nitro-phenyl)-ethoxy]-pyridin-3-yl}-2,5-dihydro-furan-2-yl)-methanol 

Relevant articles and documents

SULFONYL COMPOUNDS THAT INTERACT WITH GLUCOKINASE REGULATORY PROTEIN

The present invention relates to sulfonyl compounds that interact with glucokinase regulatory protein. In addition, the present invention relates to methods of treating type 2 diabetes, and other diseases and/or conditions where glucokinase regulatory protein is involved using the compounds, or pharmaceutically acceptable salts thereof, and pharmaceutical compositions that contain the compounds, or pharmaceutically acceptable salts thereof.

Synthesis of a dA-dT base pair analogue and its effects on DNA-ligand binding

Two nucleoside derivatives containing the base analogues 3-deazaadenine and 3-methyl-2-pyridone have been prepared as analogues of dA and dT, respectively. After conversion into the appropriately protected phosphoramidites, DNA sequences were prepared with site-specifically placed analogues. When present in a duplex DNA sequence, the analogues result in the deletion of one or both of the hydrogen bonding functional groups (the N3-nitrogen of dA and the O2-carbonyl of dT) present in the minor groove. Binding by two ligands, 4′,6-diamidine-2-phenyl indole (DAPI) and Hoechst 33258 in the minor groove has been probed using a variety of DNA sequences. These sequences contain a d(GAATTC)2 core with analogue nucleosides substituted for one or more of the dA and dT residues. DAPI bound strongly to any sequence that contained both O2-carbonyls of the central two dT residues. The presence of a dc3A residue did in some cases enhance binding. With one of the central O2-carbonyls deleted, the binding was noticeably reduced, and with both absent, no significant binding could be detected. Similar although less dramatic results were observed with Hoechst 33258 binding to analogue sequences.

Syntheses of two pyridine C-nucleosides as 'deletion-modified' analogues of dT and dC

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