166267-90-9

Basic information

• Product Name: Boc-Glu(OBzl)-Asp(OBzl)-Cys(Acm)-Lys(Z)-OBzl
• CAS NO: 166267-90-9
• Molecular Weight: 1069.24
• Mol File: 166267-90-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Boc-Glu(OBzl)-Asp(OBzl)-Cys(Acm)-Lys(Z)-OBzl(CAS DataBase Reference)
• NIST Chemistry Reference: Boc-Glu(OBzl)-Asp(OBzl)-Cys(Acm)-Lys(Z)-OBzl(166267-90-9)
• EPA Substance Registry System: Boc-Glu(OBzl)-Asp(OBzl)-Cys(Acm)-Lys(Z)-OBzl(166267-90-9)

Safety Data

• Hazardous Substances Data: 166267-90-9(Hazardous Substances Data)

Upstream product

• 13574-84-0 dicyclohexylamine salt of γ-benzyl Boc-glutamate 
• 166267-89-6 Boc-Asp(OBzl)-Cys(Acm)-Lys(Z)-OBzl 
• 77236-13-6 N-α-tert-Butyloxycarbonyl-N-ε-carbobenzoxy-L-lysine benzyl ester 
• 6366-70-7 N^ε-carbobenzoxy-L-lysine benzyl ester hydrochloride 
• 2389-45-9 Boc-Lys(Z)-OH 

Relevant articles and documents

Granulopoiesis Inhibiting Factor: Synthesis and Biological Activity

Three schemes of synthesis for pentapeptide Glp-Glu-Asp-Cys-Lys-OH were compared.Acetamidomethyl protection was used for the mercapto group of cysteine.For the same purpose, cystine was used as the starting compound for synthesis.The optimal method was shown to be the solid phase method with S-acetamidomethyl cysteine protection that can be removed by mercuric acetate before the cleavage of a peptide from a polymer.The stabilized peptide inhibits proliferation of bone marrow cells of patients with chronic myeloleukemia 5- to 20-fold and has a less pronounced effect (up to 2-fold inhibition) on peripheral blood cells.Thus, its application for the therapy of hemoblastoses is promising. Key words: granulopoiesis inhibiting factor, solid phase peptide synthesis, cysteine-containing pentapeptide