77236-13-6

Basic information

• Product Name: N-α-tert-Butyloxycarbonyl-N-ε-carbobenzoxy-L-lysine benzyl ester
• Synonyms: N-α-tert-Butyloxycarbonyl-N-ε-carbobenzoxy-L-lysine benzyl ester
• CAS NO: 77236-13-6
• Molecular Weight: 470.566
• Mol File: 77236-13-6.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: N-α-tert-Butyloxycarbonyl-N-ε-carbobenzoxy-L-lysine benzyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: N-α-tert-Butyloxycarbonyl-N-ε-carbobenzoxy-L-lysine benzyl ester(77236-13-6)
• EPA Substance Registry System: N-α-tert-Butyloxycarbonyl-N-ε-carbobenzoxy-L-lysine benzyl ester(77236-13-6)

Safety Data

• Hazardous Substances Data: 77236-13-6(Hazardous Substances Data)

Upstream product

• 2389-45-9 Boc-Lys(Z)-OH 
• 100-39-0 benzyl bromide 
• 100-44-7 benzyl chloride 

Downstream Products

• 24458-14-8 Lys(Z)-OBzl 
• 6366-70-7 N^ε-carbobenzoxy-L-lysine benzyl ester hydrochloride 
• 544477-17-0 Boc-Gly-Arg(Tos)-Pro-Ala-Lys(Z)-OBzl 
• 202411-04-9 Boc-Gln-Arg(Tos)-Pro-Ala-Lys(Z)-OBzl 
• 202411-03-8 Boc-Ala-Arg(Tos)-Pro-Ala-Lys(Z)-OBzl 
• 202411-01-6 Boc-Arg(Tos)-Pro-Ala-Lys(Z)-OBzl 
• 202410-99-9 Boc-Pro-Ala-Lys(Z)-OBzl 
• 114856-02-9 Boc-Ala-Lys(Z)-OBzl 
• 860020-55-9 N-[1-(1',3'-dioxyl-4',4',5',5'-tetramethyldihydroimidazol-2-yl)phenyl-4-yl]oxyacetyl-Gln-Arg(Tos)-Pro-Ala-Lys(Z)-OBzl 
• 860020-53-7 N-[1-(1',3'-dioxyl-4',4',5',5'-tetramethyldihydroimidazol-2-yl)phenyl-4-yl]oxyacetyl-Ala-Arg(Tos)-Pro-Ala-Lys(Z)-OBzl 
• 860020-54-8 N-[1-(1',3'-dioxyl-4',4',5',5'-tetramethyldihydroimidazol-2-yl)phenyl-4-yl]oxyacetyl-Gly-Arg(Tos)-Pro-Ala-Lys(Z)-OBzl 

Relevant articles and documents

Synthesis of the Tripeptides Tyr-Thr-Lys Phosphorylated with Isopropyl Methyl- and (Deuteromethyl)phosphonochloridates as Reference Standards for the Analysis of Biomedical Samples

A procedure for the phosphorylation of the tripeptide Tyr-Thr-Lys with isopropyl methyl- or (deuteromethyl)phosphonochloridate is developed. The phosphorylated tripeptides are intended for use as reference standards in the analysis of blood samples of people suspected to have been exposed to acetylcholinesterase inhibitors. Conditions of hromatographic separation and purification of the synthesized compounds are determined and optimized, which ensures the preparation of high-purity phosphorylated tripeptides.

A new class of β-carboline alkaloid-peptide conjugates with therapeutic efficacy in acute limb ischemia/reperfusion injury

We describe a novel class of β-carboline alkaloid-peptide conjugates that possess both free radical scavenging and thrombolytic activity. These conjugates demonstrate therapeutic efficacy in a rat arterial thrombosis assay, as well as free radical scavenging capacity as evaluated in a PC12 cell survival assay. Our results indicate that β-carboline alkaloid-peptide conjugate 26a exerts a significant protective effect against local and remote organ injury induced by limb I/R injury in the rat.

Granulopoiesis Inhibiting Factor: Synthesis and Biological Activity

Three schemes of synthesis for pentapeptide Glp-Glu-Asp-Cys-Lys-OH were compared.Acetamidomethyl protection was used for the mercapto group of cysteine.For the same purpose, cystine was used as the starting compound for synthesis.The optimal method was shown to be the solid phase method with S-acetamidomethyl cysteine protection that can be removed by mercuric acetate before the cleavage of a peptide from a polymer.The stabilized peptide inhibits proliferation of bone marrow cells of patients with chronic myeloleukemia 5- to 20-fold and has a less pronounced effect (up to 2-fold inhibition) on peripheral blood cells.Thus, its application for the therapy of hemoblastoses is promising. Key words: granulopoiesis inhibiting factor, solid phase peptide synthesis, cysteine-containing pentapeptide