166327-69-1

Upstream product

• 56269-65-9 (RS)-3-hydroxy-4-methyl-2-methylenepentanenitrile 
• 108-24-7 acetic anhydride 
• 75-36-5 acetyl chloride 

Downstream Products

• 350801-68-2 3-cyano-5-methyl-hex-3-enoic acid ethyl ester 

Relevant academic research and scientific papers

Asymmetric synthesis of pregabalin

This invention provides a method of making (S)-(+)-3-(aminomethyl)-5-methylhexanoic acid (pregabalin) or a salt thereof via an asymmetric hydrogenation synthesis. Pregabalin is useful for the treatment and prevention of seizure disorders, pain, and psychotic disorders. The invention also provides intermediates useful in the production of pregabalin.