16635-16-8Relevant academic research and scientific papers
BICYCLIC IMIDAZOL DERIVATIVES AGAINST FLAVIVIRIDAE
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Page/Page column 237, (2008/06/13)
Disclosed are compounds, compositions and methods for treatingFlaviviridae family virus infections.
Development of potent and selective factor Xa inhibitors
Rai, Roopa,Kolesnikov, Aleksandr,Li, Yong,Young, Wendy B,Leahy, Ellen,Sprengeler, Paul A,Verner, Erik,Shrader, William D,Burgess-Henry, Jana,Sangalang, Joan C,Allen, Darin,Chen, Xi,Katz, Bradley A,Luong, Christine,Elrod, Kyle,Cregar, Lynne
, p. 1797 - 1800 (2007/10/03)
The development of potent and selective small molecule inhibitors of factor Xa is described.
Chalcone-5'- and flavanone-6-carboxylic acids
Wurm,Schnetzer
, p. 717 - 719 (2007/10/02)
While 3-acetyl-4-hydroxybenzoic acid (1) reacts with the aldehydes 2a-c by Claisen-Schmidt reaction to the chalcone carboxylic acids 3a-c, the parent reaction with 2d is not successful. The chalcones 3a-b but not 3c can be transformed to the isomeric flavanone carboxylic acids 4a-b by common methods. 3c in MeOH/H2SO4 forms the methyl flavanone-carboxylate 4c which does not lead to the carboxylic acid of 4c by acid hydrolysis. Instead, 4c is split to chalcone carboxylic acid 3c quantitatively. 4'-nitroflavanone-6-carboxylic acid (4d) can only be obtained by condensation of the diketones 5a-h with 4-nitrobenzaldehyd (2d) as the methyl carboxylate, too. Here, instead of the expected α-aroylchalcone 6 or its tautomeric 3-aroylflavanone derivative, 4d is formed by hydrolytic removal of the arylcarboxylic acids 7a-b. The alkaline hydrolysis of compound 4d does not quantitatively afford the chalconecarboxylic acid 3d but results in destruction to a complex mixture of several compounds.
