1663506-80-6Relevant academic research and scientific papers
Synthetic applications of purified laccase from Pleurotus sajor caju MTCC-141
Chaurasia, Pankaj Kumar,Bharati, Shashi Lata,Singh, Sunil Kumar,Yadava, Sudha
, p. 173 - 175 (2015)
The study is devoted to the role of laccase, purified from the liquid culture medium of the indigenous fungal strain Pleurotus sajor caju MTCC-141, in selective bioconversion of toluene derivatives into substituted benzaldehydes with high yield. Coupling reactions of 3-(3,4-dihydroxyphenyl)propionic acid with 4-aminobenzoic, 4-aminoacetophenone and 1-hexylamine proceeded at room temperature under the action of laccase to give the corresponding products with excellent yields.
Selective oxidation and N-coupling by purified laccase of Xylaria polymorpha MTCC-1100
Chaurasia, Pankaj Kumar,Yadava, Sudha,Bharati, Shashi Lata,Singh, Sunil Kumar
, p. 455 - 460 (2014)
The chemical route of oxidation of methyl group to its aldehyde is inconvenient because once a methyl group is attacked, it is likely to be oxidized to the carboxylic acid and it is very difficult to stop the reaction at the aldehyde stage. Fungal laccases can be used for such oxidation reaction and the reaction can be completed sharply within 1-2 h. Coupling of amines are another important reactions known for fungal laccases; coupling reactions generally take 3-7 h. We have used the purified laccase of molecular weight 63 kDa obtained from the fungal strain Xylaria polymorpha MTCC-1100 with activity of 1.95 IU/mL for selective oxidation of 2-fluorotoluene, 4-fluorotoluene, and 2-chlorotoluene to 2-fluorobenzaldehyde, 4-fluorobenzaldehyde, and 2-chlorobenzaldehyde, respectively, and syntheses of 3-(3, 4-dihydroxyphenyl)- propionic acid derivatives by N-coupling of amines. In each oxidation reactions, ABTS was used as mediator molecule. All the syntheses are ecofriendly and were performed at room temperature.
