1663511-50-9Relevant academic research and scientific papers
A PROCESS FOR THE PREPARATION OF ANTI-INFLAMMATORY AROYLBENZOFURAN COMPOUNDS
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Page/Page column 49; 57; 58; 66; 67; 68, (2015/03/16)
Disclosed herein an efficient process for synthesis of benzofuran analogues having anti-inflammatory activity which comprises, Ru-catalyzed branched and linear selective alkylation of aroylbenzofurans formula-I with alpha, beta unsaturated esters of formula-II via C-H activation in presence of base, additives and organic solvent at suitable temperature to give high yield of desired linear alkylated benzofuran compounds of formula-III or branched alkylated benzofuran compounds of formula-IV or mixture thereof.
Ru-catalyzed branched versus linear selective C3-alkylation of 2-aroylbenzofurans with acrylates via C-H activation
Kommagalla, Yadagiri,Srinivas, Kolluru,Ramana, Chepuri V.
supporting information, p. 7884 - 7889 (2014/07/07)
The carbonyl-directed C3-H activation and alkylation of 2-aroylbenzo[b]furans with acrylates occurs selectively either in a linear or branched fashion, depending on the catalyst employed; [Ru(p-cymene)Cl 2]2 or Ru(PPh3)3Cl2, respectively. Two alternate pathways - funded upon the differences in steric and electronic preferences of these two complexes - is proposed for the selectivity of linear versus branched products. Branched-selective alkylation with acrylates has been cracked: Catalyst-dependent branched versus linear alkylation of benzofuran with acrylate has been established. [Ru(PPh3) 3Cl2] produces unusual branched-selective, alkylated adducts as major products, whereas [Ru(p-cymene)Cl2]2 selectively gives the linear, alkylated benzofuran adducts as major products (see scheme).
