27044-77-5Relevant academic research and scientific papers
Synthesis method of benzofuran compound
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Paragraph 0053-0060; 0065; 0066, (2021/05/19)
The invention belongs to the field of organic chemical synthesis, and particularly relates to a synthesis method of a benzofuran compound. According to the invention, the reaction system adopts economical and efficient iron phthalocyanine as a catalyst, a
Tandem addition/cyclization for synthesis of 2-aroyl benzofurans and 2-aroyl indoles by carbopalladation of nitriles
Gong, Julin,Hu, Kun,Shao, Yinlin,Li, Renhao,Zhang, Yetong,Hu, Maolin,Chen, Jiuxi
, p. 488 - 494 (2020/02/03)
The first example of the palladium-catalyzed tandem addition/cyclization of 2-(2-acylphenoxy)acetonitriles with arylboronic acids has been developed, providing a new strategy for the synthesis of 2-aroyl benzofurans with excellent chemoselectivity and wid
2,3-Diaroyl benzofurans from arynes: Sequential synthesis of 2-aroyl benzofurans followed by benzoylation
Neog, Kashmiri,Das, Babulal,Gogoi, Pranjal
, p. 3138 - 3150 (2018/05/17)
A cascade synthetic strategy for the direct synthesis of 2-aroyl benzofurans from aryne precursors has been developed. This reaction proceeds via C-O and C-C bond cleavage as well as C-O and C-C bond formation in a single reaction vessel. The methodology provides good yields of 2-aroyl benzofurans and tolerates a variety of functional groups. The synthesized 2-aroyl benzofurans were further benzoylated at 3-positions and one of the synthesized 2,3-diaroyl benzofuran structures was confirmed unambiguously by X-ray crystallography.
Syntheses of 2-Aroyl Benzofurans through Cascade Annulation on Arynes
Gouthami, Pashikanti,Chavan, Lahu N.,Chegondi, Rambabu,Chandrasekhar, Srivari
, p. 3325 - 3332 (2018/03/25)
The highly efficient and expedient route for the syntheses of 2-aroyl benzofurans has been developed via the cascade [2+2] followed by a [4+1] annulation on arynes. The overall transformation proceeded through the formation of ortho-quinone methide by the
Copper(I)-Catalyzed Chemoselective Reduction of Benzofuran-2-yl Ketones to Alcohols with B2pin2 via a Domino-Borylation-Protodeboronation Strategy
Xuan, Qingqing,Kong, Weiguang,Song, Qiuling
, p. 7602 - 7607 (2017/07/26)
A novel copper(I)-catalyzed chemoselective reduction of the carbonyls of benzofuran-2-yl ketones over furan rings with B2pin2 has been developed. This reaction proceeded under mild conditions. High valuable secondary alcohol derivatives of benzofurans were obtained in good to excellent yields with a broad substrate scope. The mechanistic studies suggested that a domino-borylation-protodeboronation pathway was involved in this reaction.
Palladium-catalyzed paraformaldehyde insertion: A three-component synthesis of benzofurans
Cheng, Xiufang,Peng, Yi,Wu, Jun,Deng, Guo-Jun
supporting information, p. 2819 - 2823 (2016/03/12)
An efficient procedure for 2-aroylbenzofuran preparation from 2-bromophenols, phenacyl bromides and paraformaldehyde is described. The cheap and stable paraformaldehyde served as the carbon source via an in situ formylation reaction.
Facile preparation of aromatic ketones from aromatic bromides and arenes with aldehydes
Ushijima, Sousuke,Dohi, Souya,Moriyama, Katsuhiko,Togo, Hideo
scheme or table, p. 1436 - 1442 (2012/03/09)
Aromatic ketones were efficiently prepared in good yields by the reactions of aryl bromides with n-BuLi, followed by the reactions with aromatic aldehydes or aliphatic aldehydes and the subsequent treatment with molecular iodine and K2CO3, in a one-pot method. The same treatment of arenes, instead of aromatic bromides, also provided the corresponding aromatic ketones in good yields. Using these methods, various diaryl ketones and alkyl aryl ketones bearing electron-rich aromatics and electron-deficient aromatics could be prepared efficiently by a simple, transition-metal-free, and therefore environmentally benign experimental procedure.
A straightforward conversion of aurones to 2-benzoylbenzofurans: Transformation of one class of natural products into another
Yahiaoui, Samir,Peuchmaur, Marine,Boumendjel, Ahcne
experimental part, p. 7703 - 7707 (2011/10/12)
The naturally occurring aurones (2-benzylidene-3(2H)-benzofuran-3-ones) can be easily converted to another class of natural products 2-benzoylbenzo[b] furans, via an effective reduction, acid-mediated rearrangement, and oxidation cascade. This easy conver
1-[(benzofuran-2-yl)phenylmethyl]-triazoles and -tetrazoles - Potent competitive inhibitors of aromatase
Vinh,Ahmadi,Lopez Delgado,Fernandez Perez,Walters,Smith,Nicholls,Simons
, p. 2105 - 2108 (2007/10/03)
The synthesis of a series of novel 1-[(benzofuran-2-yl)phenylmethyl]- triazoles and -tetrazoles is described. The compounds were tested for human placental aromatase inhibition in vitro, using [1β-3H]androstenedione as the substrate for the aromatase enzyme, the percentage inhibition and IC50 data is included.
Synthesis and pharmacological study of new calcium antagonists analogues of cinnarizine and flunarizine
Younes, S.,Baziard-Mouysset, G.,Saqui-Sannes, G. de,Stigliani, J. L.,Payard, M.,et al.
, p. 943 - 948 (2007/10/02)
Several phosphonic diethyl esters were synthesized and their calcium antagonistic activity evaluated in vitro.The diethyl phosphonate group was condensed on substituted , , , , and groups.Despite the presence of the diethyl phosphonate moiety and the benzhydrylpiperazinyl group, both present in potent calcium antagonist structures, only 1 of the 19 synthesis compounds exhibited a calcium antagonistic profile. diethyl phosphonate / benzhydryl piperazine / calcium antagonist
