166381-69-7

Upstream product

• 256954-23-1 ethyl 4-benzoyloxy-6-fluor-2-(2-fluoroethylthio)-7-phenylquinoline-3-carboxylate 
• 98-88-4 benzoyl chloride 
• 142856-15-3 ethyl 6-fluoro-4-hydroxy-2-(methoxymethylthio)-7-phenylquinoline-3-carboxylate 
• 256954-21-9 ethyl 4-benzoyloxy-6-fluoro-2-mercapto-7-phenylquinoline-3-carboxylate 
• 256954-19-5 ethyl 4-benzoyloxy-6-fluoro-2-(methoxymethylthio)-7-phenylquinoline-3-carboxylate 

Downstream Products

• 166380-66-1 ethyl 6-fluoro-1-fluoromethyl-4-oxo-7-phenyl-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylate 

Relevant academic research and scientific papers

Synthesis and antibacterial activity of novel 7-substituted 6-fluoro-1- methylene-4-oxo-4H-[1,3]-thiazeto[3,2-a]quinoline-3-carboxylic acid derivatives

A series of 7-substituted 6-fluoro-1-methylene-4-oxo-4H- [1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid derivatives (2) and (3) was prepared and evaluated for antibacterial activity. These compounds were obtained by the treatment of the 1-methanesulfonyloxymethyl or 1-fluoromethyl thiazetoquinolone-3-carboxylates (12, 14 and 20) with potassium hydroxide. Compounds (2) and (3) showed excellent in vitro antibacterial activity against both gram-negative and gram-positive bacteria including quinolone and Methicillin-resistant Staphylococcus aureus.