16639-46-6Relevant academic research and scientific papers
Synthesis and Antifungal Activity of Chromones and Benzoxepines from the Leaves of Ptaeroxylon obliquum
Malefo, Modibo S.,Ramadwa, Thanyani E.,Famuyide, Ibukun M.,McGaw, Lyndy J.,Eloff, Jacobus N.,Sonopo, Molahlehi S.,Selepe, Mamoalosi A.
, p. 2508 - 2517 (2020/09/15)
This study reports the first total synthesis of the bioactive oxepinochromones 12-O-acetyleranthin (8) (angular isomer) and 12-O-acetylptaeroxylinol (9) (linear isomer). The antifungal activity of these compounds and their derivatives was determined against Candida albicans and Cryptococcus neoformans. Most compounds had good selectivity between the two fungi and showed moderate to good activity. 12-O-Acetyleranthin (8) had the highest activity against C. albicans, with an MIC value of 9.9 μM, while 12-O-acetylptaeroxylinol (9), the compound present in Ptaeroxylon obliquum, had the highest activity against C. neoformans, with an MIC value of 4.9 μM.
Synthesis of the oxepinochromone natural products ptaeroxylin (desoxykarenin), ptaeroxylinol, and eranthin
Bruder, Marjorie,Haseler, Paul L.,Muscarella, Marina,Lewis, William,Moody, Christopher J.
experimental part, p. 353 - 358 (2010/03/30)
(Chemical Equation Presented) An improved synthesis of the oxepinochromone ptaeroxylin is reported, together with the syntheses of the related natural products ptaeroxylinol and eranthin. Ptaeroxylin and ptaeroxylinol were obtained from the chromenone nor
