1664-31-9

Usage

Uses

Used in Pharmaceutical Synthesis:
4-nitro-N-(2-piperidinoethyl)benzenecarboxamide is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the formation of complex molecular structures that are essential in medicinal chemistry.
Used in Organic Chemistry as a Reagent:
In the realm of organic chemistry, 4-nitro-N-(2-piperidinoethyl)benzenecarboxamide serves as a reagent, facilitating specific chemical reactions that are crucial for the development of new organic compounds.
Used in Research for Pharmacological and Biological Activities:
4-nitro-N-(2-piperidinoethyl)benzenecarboxamide is utilized in research settings to explore its potential pharmacological properties and biological activities, which could lead to the discovery of new therapeutic agents or applications in medicine.
Used as a Precursor in Drug Production:
Recognized for its potential as a precursor, 4-nitro-N-(2-piperidinoethyl)benzenecarboxamide is employed in the production process of various drugs and pharmaceutical products, highlighting its importance in the development of new medications.

Upstream product

• 27578-60-5 1-(2-aminoethyl)piperidine 
• 122-04-3 4-nitro-benzoyl chloride 
• 2038-03-1 4-(2-AMINOETHYL)MORPHOLINE 

Downstream Products

• 51-08-1 4-amino-N-(2-(piperidin-1-yl)ethyl)benzamide 

Relevant academic research and scientific papers

Comparative study of dG affinity vs. DNA methylation modulating properties of side chain derivatives of procainamide: Insight into its DNA hypomethylating effect

Procainamide derivatives have been synthesized to investigate the role of side chains in modulating the DNA methylation level in cancer cells and gain insight into its mechanism of action. The synthesized derivatives comprised of flexible (dimethyl), cons

Development of o-chlorophenyl substituted pyrimidines as exceptionally potent aurora kinase inhibitors

The o-carboxylic acid substituted bisanilinopyrimidine 1 was identified as a potent hit (Aurora A IC50 = 6.1 ± 1.0 nM) from in-house screening. Detailed structure-activity relationship (SAR) studies indicated that polar substituents at the para position of the B-ring are critical for potent activity. X-ray crystallography studies revealed that compound 1 is a type I inhibitor that binds the Aurora kinase active site in a DFG-in conformation. Structure-activity guided replacement of the A-ring carboxylic acid with halogens and incorporation of fluorine at the pyrimidine 5-position led to highly potent inhibitors of Aurora A that bind in a DFG-out conformation. B-Ring modifications were undertaken to improve the solubility and cell permeability. Compounds such as 9m with water-solubilizing moieties at the para position of the B-ring inhibited the autophosphorylation of Aurora A in MDA-MB-468 breast cancer cells.

Design, synthesis, and biological evaluation of novel water-soluble N-mustards as potential anticancer agents

A series of novel water-soluble N-mustard-benzene conjugates bearing a urea linker were synthesized. The benzene moiety contains various hydrophilic side chains are linked to the meta- or para-position of the urea linker via a carboxamide or an ether link