166409-12-7Relevant academic research and scientific papers
Exploring the antimalarial potential of the methoxy-thiazinoquinone scaffold: Identification of a new lead candidate
Imperatore, Concetta,Persico, Marco,Senese, Maria,Aiello, Anna,Casertano, Marcello,Luciano, Paolo,Basilico, Nicoletta,Parapini, Silvia,Paladino, Antonella,Fattorusso, Caterina,Menna, Marialuisa
, p. 240 - 252 (2019/01/15)
A small library of antiplasmodial methoxy-thiazinoquinones, rationally designed on the model of the previously identified hit 1, has been prepared by a simple and inexpensive procedure. The synthetic derivatives have been subjected to in vitro pharmacolog
Synthesis of various model compounds for the central tricyclic ring system of popolophuanone E
Ueki, Yasuyuki,Itoh, Masanori,Katoh, Tadashi,Terashima, Shiro
, p. 5719 - 5722 (2007/10/03)
An efficient synthesis of various model compounds 4a-e for the tricyclic core of popolophuanone E (1), a novel marine natural product, was accomplished; the method features highly regioselective annulation of the phenols 5a-e with the 2,3-dichloro-1,4-benzoquinones 7, 7c-e. Preliminary studies definitely demonstrated the feasibility of our designed synthetic strategy for 1 (the phenolic subunit I + the quinone subunit II → 1).
