166410-37-3

Basic information

• Product Name: FMOC-NH(CH2)6NH2 HCL
• Synonyms: FMOC-1,6-DIAMINOHEXANE HYDROCHLORIDE;FMOC-1,6-HEXAMETHYLENEDIAMINE HCL;FMOC-1,6-HEXAMETHYLENEDIAMINE HYDROCHLORIDE;FMOC-NH(CH2)6NH2 HCL;FMOC-DIAMINOHEXANE HCL;FMOC-HMD HCL;N-(9-FLUORENYLMETHYLOXYCARBONYL)-1,6-HEXAMETHYLENEDIAMINE HYDROCHLORIDE;N-1-(9-FLUORENYLMETHOXYCARBONYL)-1,6-DIAMINOHEXANE HYDROCHLORIDE
• CAS NO: 166410-37-3
• Molecular Formula: C₂₁H₂₆N₂O₂
• Molecular Weight: 374.9
• Mol File: 166410-37-3.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: FMOC-NH(CH2)6NH2 HCL(CAS DataBase Reference)
• NIST Chemistry Reference: FMOC-NH(CH2)6NH2 HCL(166410-37-3)
• EPA Substance Registry System: FMOC-NH(CH2)6NH2 HCL(166410-37-3)

Safety Data

• Hazardous Substances Data: 166410-37-3(Hazardous Substances Data)

Usage

Chemical Properties

White crystalline powder

Upstream product

• 124-09-4 1,6-Hexanediamine 
• 102774-86-7 9-fluorenylmethyl N-succinimidyl carbonate 
• 166410-31-7 N-fluorenylmethoxycarboxnyl-N'-tert-butoxycarbonylhexanediamine 

Downstream Products

• 872172-27-5 [6-(2-tert-butoxycarbonylamino-3-phenyl-propionylamino)-hexyl]-carbamic acid 9H-fluoren-9-ylmethyl ester 
• 945923-91-1 9H-fluoren-9-ylmethyl N-(6-aminohexyl)carbamate hydrochloride 
• 872172-28-6 [2-(3-{6-[2-tert-butoxycarbonylamino-3-(4-hydroxy-2,6-dimethyl-phenyl)-propionylamino]-hexylcarbamoyl}-3,4-dihydro-1H-isoquinolin-2-yl)-1-(4-hydroxy-2,6-dimethyl-benzyl)-2-oxo-ethyl]-carbamic acid tert-butyl ester 
• 872172-29-7 3-[6-({2-[2-tert-butoxycarbonylamino-3-(4-hydroxy-2,6-dimethyl-phenyl)-propionyl]-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl}-amino)-hexylcarbamoyl]-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester 
• 872172-30-0 [2-{3-[6-(2-tert-butoxycarbonylamino-3-phenyl-propionylamino)-hexylcarbamoyl]-3,4-dihydro-1H-isoquinolin-2-yl}-1-(4-hydroxy-2,6-dimethyl-benzyl)-2-oxo-ethyl]-carbamic acid tert-butyl ester 
• 446878-27-9 tert-butyl-N-[(S)-1-(6-aminohexylcarbamoyl)-2-phenylethyl]carbamate 
• 872172-25-3 {6-[2-tert-butoxycarbonylamino-3-(4-hydroxy-2,6-dimethyl-phenyl)-propionylamino]-hexyl}-carbamic acid 9H-fluoren-9-ylmethyl ester 

Relevant articles and documents

Flow-mediated synthesis of Boc, Fmoc, and Dd iv monoprotected diamines

A series of monoprotected aliphatic diamines (21 examples) were synthesized via continuous flow methods. The carbamates and enamines were obtained in 45-91% yields using a 0.5 mm diameter PTFE tubular flow reactor. Using readily accessible protecting group precursors, the procedure serves as an attractive alternative to existing batch-mode synthetic routes by providing direct, multigram access to N-Boc-, N-Fmoc-, and N-Ddiv-protected compounds with productivity indexes of 1.2-3.6 g/h.