16650-32-1

Basic information

• Product Name: 5,8-Difluoroquinoline
• Synonyms: 5,8-Difluoroquinoline
• CAS NO: 16650-32-1
• Molecular Formula: C₉H₅F₂N
• Molecular Weight: 165.141
• Mol File: 16650-32-1.mol

Chemical Properties

• Boiling Point: 241.8°Cat760mmHg
• Flash Point: 100°C
• Appearance: /
• Density: 1.319g/cm³
• Vapor Pressure: 0.0547mmHg at 25°C
• Refractive Index: 1.588
• CAS DataBase Reference: 5,8-Difluoroquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 5,8-Difluoroquinoline(16650-32-1)
• EPA Substance Registry System: 5,8-Difluoroquinoline(16650-32-1)

Safety Data

• Hazardous Substances Data: 16650-32-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
5,8-Difluoroquinoline is utilized as a building block for the synthesis of various drugs and pharmaceutical agents. Its unique structure allows for the creation of a range of medicinal compounds, contributing to the development of new treatments and therapies.
Used in Materials Science:
In the field of materials science, 5,8-Difluoroquinoline is studied for its potential applications, capitalizing on its chemical and physical properties to enhance or create new materials with specific characteristics for various uses.
Used in Organic Chemistry:
5,8-Difluoroquinoline also serves as an important intermediate in organic chemistry, facilitating the synthesis of complex organic molecules for a wide array of applications, from chemical research to the production of specialty chemicals.

InChI:InChI=1/C9H5F2N/c10-7-3-4-8(11)9-6(7)2-1-5-12-9/h1-5H

Upstream product

• 91-22-5 quinoline 
• 367-30-6 2,5-difluoroaniline 
• 56-81-5 glycerol 

Downstream Products

• 439-88-3 5-fluoro-8-methoxyquinoline 

Relevant articles and documents

Regioselective electrolytic 5,8-difluorination of quinolines

Electrochemical anodic oxidation method for the incorporation of fluorine atom into quinoline ring is described. Our method involves a regioselective 5,8-difluorination of quinolines using HF:pyridine as a reagent/supporting electrolyte in an undivided electrochemical cell equipped with platinum anode and cathode. Various quinoline derivatives were subjected to electrolytic fluorination at room temperature to obtain moderate to good yields in short reaction time.

Selective direct fluorination of quinoline derivatives

Direct fluorination of various quinoline derivatives in acidic reaction media gives fluorinated quinoline products arising from selective, efficient electrophilic substitution processes.

Elemental fluorine Part 15. Selective direct fluorination of quinoline derivatives

Direct fluorination of various quinoline derivatives in acidic reaction media gives fluorinated quinoline products arising from electrophilic substitution processes.

Dual stimulatory and inhibitory effects of fluorine-substitution on mutagenicity: An extension of the enamine epoxide theory for activation of the quinoline nucleus

Nineteen mono- and di-fluorinated derivatives of quinoline, 1,7- phenanthroline, 1,10-phenanthroline, benzo-[h]quinoline, and benzo[f]quinoline were subjected to analysis of their structure-mutagenicity relationships. For this purpose, six new fluorinated derivatives were synthesized. The results support that the enamine epoxide structure of the pyridine moiety, as well as the bay-region epoxide structure, is responsible for mutagenicity. Formation of K-region epoxides might involve a detoxification process rather than mutagenic activation.