16650-32-1 Usage
General Description
5,8-Difluoroquinoline is a chemical compound with the molecular formula C9H5F2N. It is an aromatic heterocyclic compound that consists of a quinoline ring with two fluorine atoms attached at the 5 and 8 positions. 5,8-Difluoroquinoline has a pale yellow color and is commonly used in the pharmaceutical industry as a building block for the synthesis of various drugs and pharmaceutical agents. It has also been studied for its potential applications in the field of materials science and organic chemistry. 5,8-Difluoroquinoline is known for its unique chemical and physical properties, and its structure makes it an important intermediate in the synthesis of complex organic molecules. However, it is important to handle this compound with care as it is a potentially hazardous material and should be used in a controlled laboratory setting.
Check Digit Verification of cas no
The CAS Registry Mumber 16650-32-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,6,6,5 and 0 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 16650-32:
(7*1)+(6*6)+(5*6)+(4*5)+(3*0)+(2*3)+(1*2)=101
101 % 10 = 1
So 16650-32-1 is a valid CAS Registry Number.
InChI:InChI=1/C9H5F2N/c10-7-3-4-8(11)9-6(7)2-1-5-12-9/h1-5H
16650-32-1Relevant articles and documents
Regioselective electrolytic 5,8-difluorination of quinolines
Spurlin, Sean,Blocker, Mark,LoBue, James,Wu, Ji,Padgett, Clifford,Shaikh, Abid
, (2020)
Electrochemical anodic oxidation method for the incorporation of fluorine atom into quinoline ring is described. Our method involves a regioselective 5,8-difluorination of quinolines using HF:pyridine as a reagent/supporting electrolyte in an undivided electrochemical cell equipped with platinum anode and cathode. Various quinoline derivatives were subjected to electrolytic fluorination at room temperature to obtain moderate to good yields in short reaction time.
Elemental fluorine Part 15. Selective direct fluorination of quinoline derivatives
Chambers, Richard D.,Holling, Darren,Sandford, Graham,Batsanov, Andrei S.,Howard, Judith A.K.
, p. 661 - 671 (2007/10/03)
Direct fluorination of various quinoline derivatives in acidic reaction media gives fluorinated quinoline products arising from electrophilic substitution processes.
