439-88-3 Usage
Uses
Used in Pharmaceutical Industry:
5-Fluoro-8-methoxyquinoline is used as a reactant in the cobalt-catalyzed hydrogenation of quinolines and related N-heteroarenes. This process is crucial for the synthesis of various pharmaceutical compounds, as it allows for the selective reduction of specific functional groups within complex organic molecules. The use of 5-fluoro-8-methoxyquinoline in this process contributes to the development of new drugs and therapeutic agents with improved efficacy and reduced side effects.
Additionally, 5-fluoro-8-methoxyquinoline may also be used as a building block or intermediate in the synthesis of other organic compounds, including those with potential applications in materials science, agrochemicals, and other industries. Its unique structure and reactivity make it a valuable component in the development of novel and innovative products.
Check Digit Verification of cas no
The CAS Registry Mumber 439-88-3 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,3 and 9 respectively; the second part has 2 digits, 8 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 439-88:
(5*4)+(4*3)+(3*9)+(2*8)+(1*8)=83
83 % 10 = 3
So 439-88-3 is a valid CAS Registry Number.
439-88-3Relevant articles and documents
Regioselectivity and relative substrate activity of difluoroquinolines containing fluorine atoms in benzene ring in reaction with sodium methoxide
Politanskaya, Larisa V.,Malysheva, Lyudmila A.,Beregovaya, Irina V.,Bagryanskaya, Irina Yu.,Gatilov, Yuri V.,Malykhin, Evgenij V.,Shteingarts, Vitalij D.
, p. 1502 - 1509 (2005)
Methoxydefluorination of 5,7-, 6,7-, 6,8-, and 5,8-difluoroquinoline (1-4) by the action of sodium methoxide has been studied in liquid ammonia and Me 2SO. The regioselectivity of methoxydefluorination of 1 and 2 in the temperature interval 218-240 K in liquid ammonia and 1 and 4 in the interval 298-378 K in Me2SO as well as the activity correlation of individual reaction centers in different substrates have been established as enthalpically controlled. The overall pattern of relative reactivity is consistent with the ab initio (RHF/6-31G*) calculated relative stabilities and electronic structures of the σ-complexes formed by the substrates with the hydroxide anion as a model nucleophile.
