166519-65-9Relevant academic research and scientific papers
Novel potent substance P and neurokinin A receptor antagonists. Conception, synthesis and biological evaluation of indolizine derivatives
Millet, Régis,Domarkas, Juozas,Rigo, Benot,Goossens, Laurence,Goossens, Jean-Fran?ois,Houssin, Raymond,Hénichart, Jean-Pierre
, p. 2905 - 2912 (2007/10/03)
Exploration of SAR around dual NK1/NK2 antagonist Cbz-Gly-Leu-Trp-OBzl(CF3)2 and its derivatives disclosed the essential requirements for more potent dual NK1/NK2 binding. We report here the synthesis and the biological properties of a novel series of indolizine including pharmacophoric elements.
L-tryptophan urea amides as NK1/NK2 Dual antagonists
Qi, Hongbo,Shah, Shrenik K.,Cascieri, Margaret A.,Sadowski, Sharon J.,MaCcoss, Malcolm
, p. 2259 - 2262 (2007/10/03)
We report that a systematic modification of an NK1 receptor selective antagonist resulted in the identification of novel compounds, 4c and 4d, with high affinity for both NK1 and NK2 receptors.
