16652-69-0

Upstream product

• 2304-98-5 N₅-[imino(nitroamino)methyl]-N₂-[(phenylmethoxy)carbonyl]-L-ornithine 
• 2149-70-4 N-nitro-L-arginine 
• 2304-98-5 N^α-benzyloxycarbonyl-N^g-nitro-L-arginine 
• 459-73-4 GlyOEt*HCl 
• 501-53-1 benzyl chloroformate 
• 1119-34-2 L-arginine hydrochloride 
• 77511-27-4 C₁₆H₃₆N⁽¹⁺⁾*C₁₄H₁₈N₅O₆^(1-) 
• 623-33-6 glycine ethyl ester hydrochloride 

Downstream Products

• 21466-92-2 N^α-benzyloxycarbonyl-N^G-nitroarginylglycine 
• 2418-67-9 L-Arg-Gly 
• 21466-92-2 ((S)-2-benzyloxycarbonylamino-5-(nitroguanidino)pentanamido)ethanoic acid 

Relevant academic research and scientific papers

ONE-POT CYCLIZATION OF A PEPTIDE BY THE USE OF (5-NITROPYRIDYL)DIPHENYL PHOSPHINATE: THE SYNTHESIS OF CYCLIC DECAPEPTIDE GRAMICIDIN S

One-pot synthesis of gramicidin S, cyclic decapeptide, was successfully achieved by treatment of the corresponding linear decapeptide with (5-nitropyridyl)diphenyl phosphinate, a new condensing reagent, in pyridine.Similarly, the phosphinic ester can be successfully employed in the Young test as well as syntheses of dipeptides.

PEPTIDE SYNTHESIS BY USING PHENYLPHOSPHONIC ESTER AS A COUPLING REAGENT

Synthesis of peptides containing various functions was efficiently accomplished by treatment of the tetrabutylammonium salts of N-protected amino acids (or peptides) with amino acid esters in the presence of bis(o- or p-nitrophenyl) phenylphosphonate.Synthesis of leucine-enkephalin was successfully achieved by the above method employing a (3+2) or (4+1) fragment coupling approach.