166522-34-5Relevant academic research and scientific papers
Synthesis of phosphonic acid alkylesteramides as structural analogues of sulfadimidine and acetophenetidin
Buseck,Neidlein
, p. 193 - 197 (2007/10/02)
The phosphonic acid alkylesteramides 19 and 36 were synthesized as structural analogues of sulfadimidine and acetophenetidin. 19 was not obtained by nucleophilic aromatic substitution, but by catalytic reduction of the corresponding nitro derivative. Condensation of the phosphonic acid diethylester 13 with aromatic aldehydes and following reduction yielded the amines 26-28.
Preparation of 3-substituted cephalosporins
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, (2008/06/13)
There is described a process for preparing an enamine of formula (IX): STR1 where R2 is a carboxylic acid protecting group and R3 is the residue of a carboxylic acid derived acyl group and where R5 and R6 are the same or different C1-4 alkyl or C7-10 aralkyl groups; or taken together with the adjacent nitrogen atom form a heterocyclic ring containing from 4 to 8 carbon atoms and optionally a further heteroatom selected from oxygen and nitrogen; by reacting a compound of formula (XII): STR2 with an amine of formula HNR5 R6, the reactant of formula (XII) being prepared by reaction of an appropriate enol derivative with a phosphorus reagent. The enamines of formula (IX) are useful in the preparation of 3-hydroxycephalosporins.
