166524-65-8 Usage
General Description
2-Ethoxy-4,6-difluoropyrimidine is a chemical compound with the molecular formula C6H6F2N2O. It is a pyrimidine derivative that contains two fluorine atoms and an ethoxy group. This chemical is commonly used in the pharmaceutical industry as an intermediate in the synthesis of various pharmaceutical compounds, including antiviral and anticancer drugs. It is also used in the development of pesticides and herbicides. 2-Ethoxy-4,6-difluoropyrimidine is of interest to researchers and chemists due to its potentially valuable properties and applications in the fields of medicine and agriculture.
Check Digit Verification of cas no
The CAS Registry Mumber 166524-65-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,6,5,2 and 4 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 166524-65:
(8*1)+(7*6)+(6*6)+(5*5)+(4*2)+(3*4)+(2*6)+(1*5)=148
148 % 10 = 8
So 166524-65-8 is a valid CAS Registry Number.
InChI:InChI=1/C6H6F2N2O/c1-2-11-6-9-4(7)3-5(8)10-6/h3H,2H2,1H3
166524-65-8Relevant articles and documents
Production process of 2-ethoxy-4, 6-difluoropyrimidine
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Paragraph 0037-0043, (2020/07/15)
The invention discloses a synthesis method of 2-ethoxy-4, 6-difluoropyrimidine, which comprises the following steps: (1) reacting urea with diethyl sulfate in an organic solvent at 60-120 DEG C to prepare an intermediate I; (2) synthesizing an intermediate II from the intermediate I and diethyl malonate; (3) performing chlorination on the intermediate II to obtain an intermediate III; and (4) reacting the intermediate III with a fluorinated reagent at 80-120 DEG C for 6 hours, and performing separation and purification to obtain the target product 2-ethoxy-4, 6-difluoropyrimidine, which has astructure described in the specification. The initial raw material urea adopted by the invention is low in price and easy to obtain, the production cost is low, the reaction process is simple and reasonable, the production safety is high, the operation is simple, and the method is suitable for industrial large-scale production.
