40758-65-4

Basic information

• Product Name: 2-ETHOXY-4,6-DICHLOROPYRIMIDINE
• Synonyms: 2-ETHOXY-4,6-DICHLOROPYRIMIDINE;4,6-DICHLORO-2-ETHOXYPYRIMIDINE
• CAS NO: 40758-65-4
• Molecular Formula: C₆H₆Cl₂N₂O
• Molecular Weight: 193.03
• Product Categories: pyrimidine;Heterocycle-Pyrimidine series
• Mol File: 40758-65-4.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 283.465 °C at 760 mmHg
• Flash Point: 125.236 °C
• Appearance: /
• Density: 1.376 g/cm³
• Vapor Pressure: 0.005mmHg at 25°C
• Refractive Index: 1.533
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -4.46±0.30(Predicted)
• CAS DataBase Reference: 2-ETHOXY-4,6-DICHLOROPYRIMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-ETHOXY-4,6-DICHLOROPYRIMIDINE(40758-65-4)
• EPA Substance Registry System: 2-ETHOXY-4,6-DICHLOROPYRIMIDINE(40758-65-4)

Safety Data

• Hazardous Substances Data: 40758-65-4(Hazardous Substances Data)

Usage

General Description

2-Ethoxy-4,6-dichloropyrimidine is a chemical compound with the molecular formula C6H6Cl2N2O. It is a pyrimidine derivative with two chlorine atoms attached to the 4th and 6th carbon positions and an ethoxy group attached to the 2nd carbon position. This chemical is commonly used in the production of pesticides and herbicides, particularly for its ability to control the growth of unwanted plants and weeds. It is also used as an intermediate in the synthesis of pharmaceuticals and other organic compounds. 2-Ethoxy-4,6-dichloropyrimidine is a white crystalline solid that is slightly soluble in water and stable under normal conditions. It is important to handle this compound with care, as it may pose health and environmental risks if not properly managed.

InChI:InChI=1/C6H6Cl2N2O/c1-2-11-6-9-4(7)3-5(8)10-6/h3H,2H2,1H3

Upstream product

• 61636-08-6 2-ethoxy-4,6-dihydroxypyrimidine 
• 3764-01-0 2,4,6-trichloropyrimidine 
• 64-17-5 ethanol 

Downstream Products

• 166524-65-8 2-ethoxy-4,6-difluoropyrimidine 

Relevant articles and documents

Production process of 2-ethoxy-4, 6-difluoropyrimidine

The invention discloses a synthesis method of 2-ethoxy-4, 6-difluoropyrimidine, which comprises the following steps: (1) reacting urea with diethyl sulfate in an organic solvent at 60-120 DEG C to prepare an intermediate I; (2) synthesizing an intermediate II from the intermediate I and diethyl malonate; (3) performing chlorination on the intermediate II to obtain an intermediate III; and (4) reacting the intermediate III with a fluorinated reagent at 80-120 DEG C for 6 hours, and performing separation and purification to obtain the target product 2-ethoxy-4, 6-difluoropyrimidine, which has astructure described in the specification. The initial raw material urea adopted by the invention is low in price and easy to obtain, the production cost is low, the reaction process is simple and reasonable, the production safety is high, the operation is simple, and the method is suitable for industrial large-scale production.

CHLOROPYRIMIDINE PROCESS

Chloropyrimidine compounds, such as 4,6-dichloro-2-ethoxypyrimidine, were prepared in good yield and good purity from the corresponding hydroxypyrimidine compounds in the absence of organic solvents and with a reduced amount of phosphorus oxychloride by carrying out the reaction in the presence of a trialkylamine compound and phosphorus trichloride. The additions of hydroxypyrimidine compound and trialkylamine compound could be made in segments. The chloropyrimidine compounds produced were recovered in an improved manner by adding chlorine to convert the chlorophosphoric acid by-products and phosphorus trichloride to phosphorus oxychloride, diluting the mixture with additional chloropyrimidine compound and removing the phosphorus oxychloride by distillation, combining the residue with water and a base, distilling the trialkylamine compound from the resulting mixture, and removing the aqueous phase.