166537-91-3

Upstream product

• 7103-09-5 4-but-1-enylmagnesium bromide 
• 874-90-8 4-methoxybenzonitrile 

Downstream Products

• 1106994-39-1 5-(bromomethyl)-3,3-difluoro-5-methoxy-2-(4-methoxyphenyl)-1-pyrroline 
• 1106994-41-5 5-(bromomethyl)-3,3-difluoro-5-methoxy-2-(3-fluoro-4-methoxyphenyl)-1-pyrroline 
• 1106994-04-0 5-(bromomethyl)-3,3-difluoro-2-(4-methoxyphenyl)-1-pyrroline 
• 1106994-06-2 5-(bromomethyl)-3,3-difluoro-2-(3-fluoro-4-methoxyphenyl)-1-pyrroline 
• 1106994-27-7 3,3-difluoro-2-(4-methoxyphenyl)-5-methylene-1-pyrroline 
• 1106994-28-8 3,3-difluoro-2-(3-fluoro-4-methoxyphenyl)-5-methylene-1-pyrroline 
• 1106994-53-9 3-fluoro-2-(4-methoxyphenyl)-1H-pyrrole-5-carbaldehyde 
• 1106994-54-0 3-fluoro-2-(3-fluoro-4-methoxyphenyl)-1H-pyrrole-5-carbaldehyde 

Relevant academic research and scientific papers

Tandem addition-bromofunctionalization of γ,δ-unsaturated Grignard reagents to benzonitriles

The tandem addition of but-3-enylmagnesium bromide to benzonitriles followed by electrophilic (Br+) trapping of the intermediate, afforded 2-aryl-5-bromomethyl-3,4-dihydro-2H-pyrroles in one step.

New synthesis of 3-fluoropyrroles

5-Alkoxymethyl-2-aryl-3-fluoro-1H-pyrroles and 2-aryl-3-fluoro-1H-pyrrole- 5-carbaldehydes were efficiently prepared from the corresponding 2-aryl-5-(bromomethyl)-1-pyrrolines via electrophilic α, α-difluorination of the imino bond, using Selectfluor (1-c