166588-72-3Relevant articles and documents
Diastereoselective α-alkylation of 2-acyl-3-phenyl-l-menthopyrazoles
Kashima,Fukuchi,Hosomi
, p. 7821 - 7824 (2007/10/02)
N-Acylpyrazoles were α-alkylated in good yields by the treatment with alkyl halides after metalation with LDA or LiHMDS. In the case of chiral N-acylpyrazoles, e.g., 2-acyl-3-phenyl-l-menthopyrazoles (4), the α-alkylation was highly diastereoselective. The subsequent α-alkylation products could be converted into esters in good yield in the presence of BF3·OEt2 without the loss of the optical purity.