1666-96-2

Upstream product

• 3422-01-3 tert-butyl phenylcarbamate 
• 7089-34-1 ((Z)-3-Dimethylamino-2-phenyl-allylidene)-dimethyl-ammonium; perchlorate 
• 108-86-1 bromobenzene 
• 591-50-4 iodobenzene 
• 181420-00-8 N-[2-(3,3-Diethoxy-prop-1-ynyl)-phenyl]-acetamide 
• 6141-21-5 N-(2-formylphenyl)-2,2-dimethylpropionamide 
• 122-78-1 phenylacetaldehyde 
• 7647-01-0 hydrogenchloride 
• 70324-23-1 1-[3]quinolyl-3,3-dimethyl-triazene 
• 71-43-2 benzene 
• 14933-29-0 3-phenyl-quinoline-2,4-diol 
• 247222-84-0 2-(2-phenylethynyl)phenyl isocyanide 
• 120-72-9 indole 
• 5332-24-1 3-bromoquinoline 

Downstream Products

• 116186-64-2 1-benzyl-3-phenyl-quinolinium; chloride 
• 78317-98-3 (rac)-3-phenyl-1,2,3,4-tetrahydroquinoline 
• 579-93-1 2-(Benzoylamino)benzoic Acid 
• 101161-83-5 3-phenyl-5,6,7,8-tetrahydroquinoline 
• 25308-72-9 3-phenylquinoline N-oxide 
• 107916-43-8 3-(4-nitrophenyl)quinoline 
• 243-47-0 benzo[4,5]thieno[2,3-b]quinoline 
• 38035-81-3 3-phenyl-quinolin-2-ol 
• 104967-74-0 3-(p-aminophenyl)-quinoline 
• 107915-36-6 3-(p-hydroxyphenyl)-quinoline 
• 101101-67-1 3-(4-amino-phenyl)-[5]quinolylamine 
• 106523-22-2 3-(4-nitro-phenyl)-quinoline-1-oxide 
• 38035-82-4 3-(4-nitro-phenyl)-quinolin-2-ol 
• 107943-58-8 2-chloro-3-(4-nitrophenyl)quinoline 

Relevant academic research and scientific papers

PALLADIUM-CATALYZED SYNTHESIS OF QUINOLINES FROM ALLYLIC ALCOHOLS AND o-IODOANILINE

The palladium-catalyzed coupling of allylic alcohols and o-iodoaniline provides a convenient, one-step synthesis of quinolines.

An isonitrile-alkyne cascade to di-substituted indoles

Intramolecular tin and sulfur mediated free-radical cyclizations between an aryl isonitrile and a pendant TMS-substituted alkyne give 2,3- disubstituted indoles from 5-exo-dig cyclization and nucleophilic trapping of the resulting indolenine intermediate.

SBA-15-type organosilica with 4-mercapto-N,N-bis-(3-Si-propyl)butanamide for palladium scavenging and cross-coupling catalysis

This work describes the synthesis of novel functional silica materials with difunctional thiol-amide substructures and featuring regular architectures on a mesoscopic level. The functional materials were synthesised by both one-pot co-condensation and post-grafting approaches. The thiol groups confined in the matrix were found to be efficient for palladium entrapment, leading to highly active and reusable heterogeneous catalysts for Sonogashira and Suzuki-Miyaura cross-coupling reactions. This work evidences the crucial role of both the thiol precursor and the condensation degree of the silica scaffold in view of the design of stable and reusable tailor-made mesoporous catalytic silica materials.

Suzuki-miyaura cross-coupling reactions in a Solkane365/227/ethanol blend at ambient temperature

An environmentally benign solvent system, Solkane365/227/ethanol blend, was developed for Suzuki-Miyaura cross-coupling reactions of aryl boronic acids and aryl halides. The reaction is quite general and gives excellent yields for various aryl, heteroaryl, and fluoroaryl boronic acids or halides. Interestingly, this system also allows the synthesis of polyaryls.

Imidazolium supported palladium-chloroglycine complex: Recyclable catalyst for Suzuki-Miyaura coupling reactions

1-Glycyl-3-methyl imidazolium chloride-palladium(II) complex [[Gmim]Cl-Pd(II)] was found to be a catalyst for the Suzuki-Miyaura reaction with excellent yields with high turnover number (6.5 × 102-9.4 × 102).

PEPPSI-Pd-NHC catalyzed Suzuki-Miyaura cross-coupling reactions in aqueous media

A series of unsymmetrical 1,3-disubstituted benzimidazolium chlorides were synthesized as N-heterocyclic carbene (NHC) precursors. These compounds were used to synthesize of the PEPPSI-type palladium NHC complexes. The structures of all compounds were cha

Pd Nanoparticles Dispersed on ZrIV Organophosphonate: A Robust and Reusable Catalyst for Suzuki–Miyaura Cross-Coupling Reactions

A mesoporous zirconium(IV) phosphonate was synthesized by the hydrothermal reaction of ZrOCl2·8H2O with a trisphosphonic acid ligand, mesityl-1,3,5-tris(methylenephosphonic acid). Treatment of the mesoporous ZrIV phosphonate framework with Pd(OAc)2 and subsequent reduction produced a nanocomposite where Pd nanoparticles of average size ca. 7–8 nm were found to be homogeneously and abundantly dispersed over the phosphonate framework. The composite acts as an efficient and reusable heterogeneous catalyst in the Suzuki–Miyaura cross coupling reaction of aryl bromides with aryl boronic acids.

Copper-catalyzed synthesis of substituted quinolines via C-N coupling/condensation from ortho -acylanilines and alkenyl iodides

An efficient cascade copper-catalyzed intermolecular Ullmann-type C-N coupling/enamine condensation reaction is described, in which ortho-acylanilines and alkenyl iodides converted to multisubstituted quinolines in good to excellent yields.

Reusable polymer-supported palladium catalysts: An alternative to tetrakis(triphenylphosphine)palladium in the suzuki cross-coupling reaction

The Suzuki cross-coupling reaction of a boronic acid and a bromoaromatic requires palldium catalysis. Almost identical yields were obtained in the usual conditions, with 30 mequiv. of Pd(PPh3)4, and with 2 mequiv of a polymer-supported catalyst, which was easily prepared in two steps from Merrified polymer. Recovery and reuse of the catalyst is easy, and only 0.60% of the initial amount of palladium is lost during a reaction.

From the grafting of NHC-based Pd(II) complexes onto TiO2 to the in situ generation of Mott-Schottky heterojunctions: The boosting effect in the Suzuki-Miyaura reaction. Do the evolved Pd NPs act as reservoirs?

The assumption that the real active species involved in the Suzuki-Miyaura reaction are homogeneous, heterogeneous or both is often proposed. However a lack of characterization of the true catalytic entities and their monitoring makes assumptions somewhat elusive. Here, with the aim of getting new insights into the formation of active species in the Suzuki-Miyaura reaction, a family of palladium(II) complexes bearing bis(NHC) ligands was synthesized for immobilization at the surface of TiO2. The studies reveal that once the complexes are anchored onto TiO2, the mechanism governing the catalytic reaction is different from that observed for the non-anchored complexes. All complexes evolved to Pd NPs at the surface of TiO2 under reaction conditions and released Pd species in the liquid phase. Also, this reactivity was boosted by the in situ generation of Mott-Schottky heterojunctions, opening new routes towards the design of heterogenized catalysts for their further implementation in reverse-flow reactors.